Aerosol generating and delivery device
Inventors
Giroux, Marc • DeGroodt, William A. • Pearce, Joseph R. • Kamp, Robert W. • Rinne, Finn O. • Leung, Paul C.
Assignees
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Publication Number
US-8733342-B2
Publication Date
2014-05-27
Expiration Date
Abstract
Particular aspects provide novel atomizers for generating particles over a broad range of MMAD size distributions, the eliminating the requirement for an impaction baffle in generating the desired particle sizes. In particular aspects, the atomization means communicates with a remote particle filter member configured and positioned to provide for particle size filtering. In additional aspects, the atomization means communicates with a particle dispersion chamber suitable to impart a desired particle flow pattern to particles within and exiting the dispersion chamber. In further aspects, the atomization means communicates with a nasal, ocular, oral or ‘vicinity’ adapter. The novel devices provide for targeted (e.g., nasal, ocular, oral, local vicinity), systemic, and/or topical delivery of an atomized liquid (e.g., via the nasal cavity, olfactory region, and mouth). Further exemplary aspects relate to aerosolization and delivery of perfume, fragrance, essential oil or cosmeceutical agents and the like.
Core Innovation
The invention relates to an aerosol generating and/or delivery device for targeting nasal, ocular, oral, and vicinity delivery. Compressed fluid is supplied to an atomization means that includes a compressed fluid exit orifice and a liquid feed channel with a liquid exit orifice, and the compressed-fluid jet interacts with a diverting wall and/or diverting portion of an end-wall face to atomize liquid using diverting disruptive atomization rather than relying on closely spaced impaction baffles.
In the device, an aerodynamic particle size filtering member is positioned remotely from an orifice plane and non-collisionally passes desired aerosol particle sizes while returning larger particles to atomization chamber reservoir or holding means, including without violent shattering. This provides aerosol particle size control using an aerodynamic size filtering member in combination with the diverted atomization structure.
The device further includes a particle dispersion chamber that imparts a controllable flow and/or velocity pattern to aerosol particles, including vortical, turbulent, and randomized flow patterns. Delivery is supported using nasal adapter, ocular adapter, oral adapter, and vicinity adapters that maintain particle-flow patterns and provide sealing for improved delivery and retention, and the system is described as capable of delivering medicaments and other agents.
Claims Coverage
Not explicitly described in patent.
Not explicitly described in patent.
Stated Advantages
Avoids reliance on closely spaced impaction baffles and their high recycling levels (e.g., 93–99% recycling on baffles).
Improves handling of higher viscosity liquids.
Provides broader MMAD particle size distribution ranges.
Improves delivery and retention through adapters providing sealing and maintaining particle-flow patterns.
Enables aerosol particle size control using an aerodynamic particle size filtering member and controlled dispersion chamber flow patterns.
Documented Applications
Delivery of medicaments and pharmaceutical agents to nasal delivery targets including nasal cavity, paranasal sinuses, and olfactory region.
Delivery of medicaments and/or agents for ocular delivery to an eye.
Delivery of medicaments and/or agents for oral delivery to a mouth.
Delivery of agents to a delivery target described as vicinity.
Delivery of non-medical agents such as perfume, fragrance, essential oils, cosmeceuticals, moisturizing agents, lotions, air fresheners, and deionizing/aromatherapeutic agents.
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