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Publication Number
US-8721582-B2
Publication Date
2014-05-13
Expiration Date
Abstract
An internal dry powder delivery system through a working channel of an endoscopic cannula for directly applying the powder form medication to an internal tissue/organ site, includes an elongated tubular delivery channel and a powder supply device for producing pressurized gas mixing with the dry powder for feeding to form a mixture of dry powder and pressurized gas delivering to an internal tissue/organ site through the delivery channel via endoscopic cannula. It ensures a smooth powder release by preventing liquid from accumulation at the tip of the delivery channel and offers physicians a new powder form drug delivery method via endoscope. Also, it offers new minimal invasive application by directly and precisely applying the powder format drug to the internal sites of human gastrointestinal organ via endoscope to achieve hemostasis, anti-inflammation, anti-ulcer and anti-tumor treatment, etc.
Core Innovation
The invention provides a method of delivering dry powder to an internal operation site of beings. A flexible elongated tubular delivery channel is extended via an endoscope so that the distal end is positioned adjacent to the internal operation site, wherein the delivery channel is longer than the endoscope. An operation channel is extended along with the delivery channel, and an operation cable is extended within the operation channel to an end cap connected to a handle.
The method includes normally covering an emitting opening of the distal end of the delivery channel with the end cap, and opening the end cap by actuation of the handle after the distal end reaches the position adjacent to the internal operation site. Pressurized gas is produced and mixed with dry powder to form a mixture of dry powder and pressurized gas in a gas-powder chamber communicating with a feeding opening of the delivery channel. The mixture is continuously fed from the gas-powder chamber into the delivery channel via the feeding opening.
A predetermined amount of the mixture of dry powder and pressurized gas is sprayed out from the emitting opening of the distal end of the delivery channel for application onto the internal operation site. The disclosure further describes an endoscope-delivered internal dry powder system that addresses occlusion issues related to long and narrow channels and to liquid/air mixing. The system is configured to apply the mixture onto internal tissue sites using the gas-powder chamber and delivery channel, with an end cap mechanism preventing body fluid ingress until actuation at the target location.
Claims Coverage
The disclosed claims include one independent method claim. The method claim contains three inventive features covering an endoscope-delivered flexible delivery channel with an end cap actuation mechanism, a gas-powder chamber that mixes dry powder and pressurized gas, and continuous feeding of the mixture for spraying onto an internal operation site.
Endoscope-delivered flexible elongated tubular delivery channel with end cap actuation
Extending a distal end of a flexible elongated tubular delivery channel via an endoscope to a position adjacent to an internal operation site, wherein the delivery channel is longer than the endoscope, with an operation cable connected to an end cap that normally covers an emitting opening and is opened by actuation of a handle after the distal end reaches the position adjacent to the internal operation site.
Gas-powder chamber mixing and communicating feeding opening
Producing pressurized gas and mixing the pressurized gas with dry powder to form a mixture in a gas-powder chamber, wherein the gas-powder chamber communicates with a feeding opening of the delivery channel.
Continuous feeding and spraying predetermined amount at emitting opening
Continuously feeding the mixture from the gas-powder chamber into the delivery channel via the feeding opening until a predetermined amount of the mixture sprays out from the emitting opening of the distal end of the delivery channel for application onto the internal operation site.
Across the independent claim, the inventive coverage is grounded in positioning a flexible elongated delivery channel via an endoscope with an end cap that is opened at the target site, forming a dry powder/pressurized gas mixture in a gas-powder chamber that communicates with the delivery channel, and continuously feeding the mixture until a predetermined amount sprays from the emitting opening for application onto the internal operation site.
Stated Advantages
Overcomes occlusion issues caused by long and narrow channels and by liquid/air mixing.
Documented Applications
Hemostasis application using a starch-derived absorbable polysaccharide hemostat (SAPH) for bleeding control at an internal operation site.
Anti-inflammation application using an anti-inflammatory drug at an internal operation site.
Anti-ulcer application using an anti-ulcer drug at an internal operation site.
Anti-tumor/anti-neoplastic treatment application using anti-neoplastic drugs and/or cytotoxic agents, hormones, and biological response modifier-related treatment at an internal operation site.
Illustrating agent application for cancer/tumor sites in a gastro-intestinal wall via an endoscope during a minimally invasive procedure for inspection of tissue disorder.
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