Therapeutic hybrid implantable devices
Inventors
Bodor, Nicholas • Buchwald, Peter • Fraker, Christopher A. • Hubbell, Jeffrey • Inverardi, Luca • Kenyon, Norma Sue • Latta, Paul • Pileggi, Antonello • Anderson, Cheryl Stabler • Grassi, Fabio • Ricordi, Camillo
Assignees
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Publication Number
US-8702684-B2
Publication Date
2014-04-22
Expiration Date
Abstract
A device (10) for receiving implanted biological material includes a mechanoprotective surface (16) defining an adjacent space, an assembly (26, 28) for locally delivering media to said space, and a pump or slow/sustained release reservoir structure (14) operatively coupled to the assembly. The device may comprise an additional plunger body for being disposed in said space. The implanted biological material may be encapsulated or non-encapsulated.
Core Innovation
The invention relates to therapeutic hybrid implantable devices for receiving implanted biological material comprising one or more cell types or tissues. The device includes a mechanoprotective surface defining an adjacent space for receiving the implanted biological material, where the mechanoprotective surface has a porosity that permits vasculature to reach the adjacent space. This adjacent space is configured to receive nanoencapsulated biological material and to support vascular access for ingrowth.
The device further includes at least one agent formulated or encapsulated to provide slow/sustained release delivery to the implanted biological material. In at least one embodiment, the agent is or comprises at least one factor selected from an oxygen generating product, an oxygen releasing product, an oxygen transport enhancing product, and an immunosuppressive agent. In another embodiment, the agent comprises oATP, where oATP is formulated or encapsulated for slow/sustained release delivery to the implanted biological material.
A method of implanting the biological material is provided that includes implanting into a patient a device having the mechanoprotective porous surface with an adjacent space, an agent for slow/sustained release delivery, and a plunger element in the adjacent space. The method includes waiting for a period of time sufficient for ingrowth of vascular tissue into the adjacent space, removing the plunger element, and depositing the biological material into the space vacated by the plunger element. The slow/sustained release delivery of the at least one agent continues to the biological material after plunger removal.
Claims Coverage
The partial content provides three independent claims. Across the independent claims, the inventive coverage centers on a mechanoprotective porous surface with an adjacent space reachable by vasculature, combined with slow/sustained release delivery of oxygen-related products and/or immunosuppressive agents, including oATP, and a plunger-based pre-vascularization sequence.
Mechanoprotective porous surface with vasculature-accessible adjacent space
A device includes a mechanoprotective surface defining an adjacent space for receiving the implanted biological material, wherein the mechanoprotective surface has a porosity which permits vasculature to reach the adjacent space.
Slow/sustained release oxygen-factor and/or immunosuppressive delivery agent
The device includes at least one agent formulated or encapsulated to provide slow/sustained release delivery to the implanted biological material, wherein the agent is or comprises at least one factor selected from the group consisting of an oxygen generating product, an oxygen releasing product, an oxygen transport enhancing product, and an immunosuppressive agent.
Slow/sustained release oATP agent
The device includes at least one agent formulated or encapsulated to provide slow/sustained release delivery to the implanted biological material, wherein the agent is or comprises oATP.
Plunger element pre-vascularization and deposition of biological material
A method includes implanting into the patient a device comprising a mechanoprotective surface defining an adjacent space, at least one agent for slow/sustained release delivery, and a plunger element in the adjacent space; waiting for a period of time sufficient for ingrowth of vascular tissue into the adjacent space; removing the plunger element and depositing the biological material into the space vacated by the plunger element, and providing slow/sustained release delivery of the at least one agent to the biological material.
Claim coverage is directed to implantable devices and implantation methods combining a mechanoprotective porous surface that enables vasculature to reach an adjacent space with slow/sustained release delivery of oxygen-related factors and/or immunosuppressive agents, including a specified oATP option. The method claim further covers a plunger-based sequence that supports vascular tissue ingrowth before depositing the biological material into the vacated space while continuing slow/sustained release delivery.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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