Ventilation circuit adaptor and proximal aerosol delivery system

Inventors

Mazela, Jan • Henderson, Christopher

Assignees

Windtree Therapeutics Inc

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Publication Number

US-8701658-B2

Patent

Publication Date

2014-04-22

Expiration Date


Abstract

An adaptor for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation includes an aerosol flow channel having an aerosol inlet port and a patient interface port, and defining an aerosol flow path from the aerosol inlet port to and through the patient interface port; and a ventilation gas flow channel in fluid communication with the aerosol flow channel and having a gas inlet port and a gas outlet port, and defining a ventilation gas flow path from the gas inlet port to and through the gas outlet port, wherein the ventilation gas flow path is at least partially offset from the aerosol flow path and at least partially encircles the aerosol flow path. Systems and methods for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation incorporate the adaptor.

Core Innovation

The invention relates to a ventilation circuit adaptor for providing ventilation gas and aerosol, where the adaptor includes an aerosol flowpath and a ventilation gas flowpath. The adaptor has an aerosol flow chamber extending along a longitudinal axis from an aerosol inlet port to a patient interface port, and an aerosol flow channel is disposed coaxially with the chamber and extends from an aerosol flow channel inlet port to an aerosol flow channel outlet port recessed within the chamber and in fluid communication with the patient interface port.

The aerosol flow channel outlet port is recessed longitudinally within the aerosol flow chamber, with a cross-sectional area at the outlet port smaller than a cross-sectional area of the aerosol flow chamber. This forms an annular zone bounded by the outer wall surface of the aerosol flow channel and the inner wall surface of the aerosol chamber, with the annular zone in fluid communication with the patient interface port.

The adaptor also includes a ventilation gas flow chamber that extends from a ventilation gas inlet port through the wall in the aerosol flow chamber, through and in fluid communication with the annular zone and the patient interface, and through the wall in the aerosol flow chamber to a ventilation gas outlet port. As a result, the ventilation gas flowpath extends from the ventilation gas inlet port through the annular zone to the ventilation gas outlet port.

Claims Coverage

The provided independent claim coverage includes one independent claim. The claim specifies two interacting flow structures: an aerosol chamber/channel and a ventilation gas chamber forming an annular zone, arranged to deliver aerosol and ventilation gas to a patient interface port.

Coaxial aerosol flow channel with recessed aerosol outlet and annular zone patient interface communication

An adaptor with an aerosol flow chamber and a coaxial aerosol flow channel, where the aerosol flow channel outlet port is recessed within the aerosol flow chamber, the outlet port forms an annular zone with the chamber wall, and the annular zone is in fluid communication with the patient interface port such that the aerosol flowpath extends through the aerosol flow channel and out to the patient interface port.

Annular ventilation gas routing through the aerosol chamber via ventilation gas flow chamber

A ventilation gas flow chamber that extends from a ventilation gas inlet port through the wall in the aerosol flow chamber, through and in fluid communication with the annular zone and the patient interface, and through the wall to a ventilation gas outlet port, so that the ventilation gas flowpath extends from the ventilation gas inlet port through the annular zone to the ventilation gas outlet port.

The independent claim defines an adaptor architecture in which a coaxial aerosol flow channel with a recessed aerosol outlet communicates with the patient interface, while ventilation gas is routed through a ventilation gas flow chamber into and out of an annular zone connected to the patient interface.

Stated Advantages

Not explicitly described in patent.

Documented Applications

Not explicitly described in patent.

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