Method for treating a surface with a coating comprising a microencapsulated therapeutic agent and device with treated surface
Inventors
Dudnyk, Vyacheslav • DiTizio, Valerio
Assignees
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Publication Number
US-8697112-B2
Publication Date
2014-04-15
Expiration Date
Abstract
A method for treating a surface with a therapeutic agent is disclosed. The method comprises precipitating a therapeutic agent from a hydrophilic polymeric base layer with which the therapeutic agent has been complexed, to form a layer comprising microparticles of the therapeutic agent on the hydrophilic polymeric base layer, the hydrophilic polymeric base layer being grafted to the surface. Devices comprising a surface having a hydrophilic polymeric base layer comprising a hydrophilic polymer grafted to the surface and a layer comprising microparticles of a therapeutic agent disposed on and complexed with the hydrophilic polymeric base layer are also disclosed.
Core Innovation
A device is provided that includes a surface with a hydrophilic polymeric base layer comprising a hydrophilic polymer grafted to the surface. The device further includes a layer comprising microparticles of a therapeutic agent disposed on and complexed with the hydrophilic polymeric base layer. The therapeutic-agent microparticles are formed by complexing the therapeutic agent with the grafted hydrophilic polymer and precipitating the complex to create a layer on the surface.
The therapeutic-agent materials include silver salts, including silver nitrate, and antimicrobial agents including chlorhexidine digluconate. The coating is compatible with hydrophilic polymeric base layers and optional hydrophobic polymeric top layers. An optional hydrophobic polymeric top layer can be disposed over the therapeutic-agent microparticle layer to regulate release.
Example device components include an implantable medical device component such as a catheter. The described material options include both hydrophilic and hydrophobic polymeric materials. The partial content also describes resulting microparticle and microcrystal size and loading trends tied to the described layer formation approach and layer structure.
Claims Coverage
The independent claim defines a multilayer device architecture with three core inventive aspects: a hydrophilic polymeric base layer with a hydrophilic polymer grafted to the surface, a therapeutic-agent microparticle layer disposed on and complexed with the hydrophilic base layer, and the therapeutic agent present as microparticles within the complexed layer. Dependent claims further refine therapeutic-agent identity, structural dimensions, an optional hydrophobic top layer, and medical-device indications.
Hydrophilic polymeric base layer grafted to the surface
A hydrophilic polymeric base layer comprising a hydrophilic polymer grafted to the surface.
Layer of therapeutic-agent microparticles disposed on and complexed with the base layer
A layer comprising microparticles of a therapeutic agent disposed on and complexed with the hydrophilic polymeric base layer.
Therapeutic-agent selected as silver nitrate
The therapeutic agent includes silver nitrate.
Microparticle dimensions of the therapeutic agent
Microparticles of the therapeutic agent have particle dimensions ranging from about 1 μm to about 500 μm.
Hydrophilic base-layer thickness range
A hydrophilic polymeric base layer having a thickness range of about 0.1 μm to about 500 μm.
Hydrophobic polymeric top layer over the therapeutic-agent layer
A hydrophobic polymeric top layer over the therapeutic agent layer.
Medical-device configuration for pleurodesis, restenosis prevention, or tumor treatment
A medical device configured for inducing pleurodesis, preventing restenosis, or treating tumors.
Across the independent claim and its dependent refinements, the claimed subject matter is centered on a hydrophilic polymer grafted base layer on a surface and a therapeutic-agent microparticle layer disposed on and complexed with that base layer, with further refinements specifying therapeutic agent identity, microparticle and base-layer dimension constraints, an optional hydrophobic top layer, and medical-device indications.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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