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Assignees
MemberIntralytixIntralytixIntralytix is a biotechnology company specializing in bacteriophage-based solutions for controlling pathogenic bacteria in food safety, human and animal health, dietary supplements, environmental sanitation, and veterinary applications. The company utilizes lytic bacteriophages for targeted, non-chemical interventions and operates with in-house cGMP manufacturing, a broad patent portfolio, and ongoing clinical research, applying AI and machine learning in phage discovery and process optimization. Intralytix supports industry and academic progress through conference sponsorships and collaborative projects.
Intralytix is a biotechnology company specializing in bacteriophage-based solutions for controlling pathogenic bacteria in food safety, human and animal health, dietary supplements, environmental sanitation, and veterinary applications. The company utilizes lytic bacteriophages for targeted, non-chemical interventions and operates with in-house cGMP manufacturing, a broad patent portfolio, and ongoing clinical research, applying AI and machine learning in phage discovery and process optimization. Intralytix supports industry and academic progress through conference sponsorships and collaborative projects.
Publication Number
US-8685696-B2
Publication Date
2014-04-01
Expiration Date
Abstract
The present invention is directed to isolated bacteriophages having specificity and lytic activity against strains of Salmonella species, methods of using the bacteriophages, progeny and derivatives derived therefrom, to control the growth of Salmonella species in various settings (e.g., food safety, sanitation, probiotics).
Core Innovation
The disclosed subject matter relates to isolated bacteriophages deposited under ATCC Accession Nos. PTA-12381, PTA-12382, PTA-12379, PTA-8365, PTA-12380, PTA-8366, and PTA-8367, including bacteriophage STML-198, SNN-387, SEML-239-1, STML-12-1, SKML-39, SEML-24, and STA-202. The bacteriophages have lytic activity against Salmonella strains, and variants thereof.
The variants retain the phenotypic characteristics of the deposited bacteriophage while maintaining lytic activity against Salmonella strains. The document further describes progeny and substantially equivalent bacteriophages and indicates that identifying information can be provided using RFLP-based identification to support distinguishing and detecting related phage materials.
Compositions containing at least one of the isolated bacteriophages are disclosed, including compositions for use in reducing the incidence of food borne illnesses caused by Salmonella strains. The document also includes disclosed uses relating to food-safety decontamination of food and food-contact equipment/surfaces, environmental control including biofilm control, and diagnostic and epidemiological typing using detection concepts associated with phage-mediated lysis.
Claims Coverage
The document includes two independent claims. Across them, the coverage centers on specific deposited isolated lytic Salmonella bacteriophages with variants that retain phenotypic characteristics, and a method for reducing food borne illness incidence by contacting food products with a lytic bacteriophage composition.
Deposited isolated lytic Salmonella bacteriophages and variants
An isolated bacteriophage STML-198 deposited under ATCC Accession No. PTA-12381, SNN-387 deposited under ATCC Accession No. PTA-12382, SEML-239-1 deposited under ATCC Accession No. PTA-12379, STML-12-1 deposited under ATCC Accession No. PTA-8365, SKML-39 deposited under ATCC Accession No. PTA-12380, SEML-24 deposited under ATCC Accession No. PTA-8366, or STA-202 deposited under ATCC Accession No. PTA-8367, having lytic activity against Salmonella strains, and variants thereof, wherein the variants retain the phenotypic characteristics of the bacteriophage and have lytic activity against Salmonella strains.
Reducing incidence of food borne illnesses by contacting food with a lytic bacteriophage composition
A method for the reduction in the incidence of food borne illnesses caused by Salmonella strains comprising contacting a food product or products with a microbial growth inhibiting effective amount of a bacteriophage composition comprising at least one of the specified isolated bacteriophages, and variants thereof, wherein the variants retain the phenotypic characteristics of the bacteriophage and have lytic activity against Salmonella strains.
Overall claim coverage is directed to specific deposited isolated lytic Salmonella bacteriophages and variants that retain phenotypic characteristics, and to a food-illness reduction method using a bacteriophage composition containing at least one of the specified lytic phages.
Stated Advantages
Reduce the incidence of food borne illnesses caused by Salmonella strains.
Documented Applications
Food-safety decontamination by contacting food products and food-contact equipment/surfaces with lytic Salmonella-specific bacteriophage compositions.
Environmental decontamination including biofilm control.
Animal/human infection prevention and treatment concepts including probiotic composition concepts.
Diagnostic and epidemiological typing using phage-associated detection concepts.
Vaccine/bacterin preparation using phage-related materials.
Use in a pet food product containing at least one isolated bacteriophage.
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