Diagnostic gel composition, method for making a diagnostic gel composition
Inventors
Dendukuri, Dhananjaya • Katiyar, Reeta • Sivakumaran, Lakshmi P.
Assignees
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Publication Number
US-8647742-B2
Publication Date
2014-02-11
Expiration Date
Abstract
The invention relates to a diagnostic gel composition for use as a diagnostic element in diagnostic devices. The diagnostic gel composition is derived from a compound having a formula D-Sp-Po wherein D is a diagnostic group; Sp is a hydrophilic spacer group; and Po is a polymerizable group. The diagnostic gel composition of the invention has dimensions ranging from about 250 nanometers to about 1000 micrometers, and a Young's modulus ranging from about 10 kilopascals to about 200 kilopascals. The invention also provides method for making the diagnostic gel composition. The method comprises providing a composition comprising a porogen, an initiator and a compound having a formula D-Sp-Po; polymerizing the composition to form a polymerized composition; and washing the polymerized composition to form the diagnostic gel composition.
Core Innovation
The invention provides a diagnostic gel composition characterized by dimensions ranging from about 250 nanometers to about 1000 micrometers and a Young’s modulus ranging from about 10 kilopascals to about 200 kilopascals. The diagnostic gel composition is derived from a compound having a formula D-Sp-Po, where D is a diagnostic group, Sp is a hydrophilic spacer group, and Po is a polymerizable group.
The disclosure further defines the gel composition as including pores having a pore-size range from about 5 nanometers to about 1000 nanometers. The disclosure provides examples for the group definitions, including D as an antibody, Sp as a poly(ethylene glycol) based group, and Po as a vinyl group, so the diagnostic gel composition is tuned in structural dimensions, mechanical stiffness, and optional pore size while incorporating a diagnostic group for binding and detection.
The disclosure also provides a method of making the diagnostic gel composition by providing a composition comprising a porogen, an initiator, and a compound having a formula D-Sp-Po, polymerizing the composition to form a polymerized composition, and washing the polymerized composition to form the diagnostic gel composition. The resulting diagnostic gel composition is described as having a Young’s modulus ranging from about 10 kilopascals to about 200 kilopascals.
Claims Coverage
The independent claim set includes three inventive features: the diagnostic gel composition, a diagnostic element comprising the diagnostic gel composition, and a method of making the diagnostic gel composition. The inventive features cover defined gel dimensions and Young’s modulus derived from a D-Sp-Po compound, optional pores with a defined pore-size range, and process steps using a porogen and initiator with D-Sp-Po followed by polymerizing and washing.
Diagnostic gel composition with defined dimensions and Young’s modulus from D-Sp-Po
A diagnostic gel composition having dimensions ranging from about 250 nanometers to about 1000 micrometers, and a Young’s modulus ranging from about 10 kilopascals to about 200 kilopascals, wherein the diagnostic gel composition is derived from a compound having a formula D-Sp-Po, where D is a diagnostic group, Sp is a hydrophilic spacer group, and Po is a polymerizable group.
Diagnostic element comprising the diagnostic gel composition
A diagnostic element comprising the diagnostic gel composition.
Method of making the diagnostic gel composition using a porogen and initiator with D-Sp-Po, then polymerizing and washing
A method of making a diagnostic gel composition comprising providing a composition comprising a porogen, an initiator and a compound having a formula D-Sp-Po; polymerizing the composition to form a polymerized composition; washing the polymerized composition to form the diagnostic gel composition; wherein D is a diagnostic group, Sp is a hydrophilic spacer group, Po is a polymerizable group, and wherein the diagnostic gel composition has a Young’s modulus ranging from about 10 kilopascals to about 200 kilopascals.
Overall claim coverage centers on a diagnostic gel composition defined by specified dimensions and Young’s modulus derived from a D-Sp-Po compound. The claims additionally cover a diagnostic element comprising that gel and a corresponding manufacturing method using a porogen and initiator with D-Sp-Po, followed by polymerizing and washing to obtain the diagnostic gel.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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