Device for promotion of hemostasis and/or wound healing
Inventors
Larsen, Kristian • Sabra, Mads
Assignees
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Publication Number
US-8642831-B2
Publication Date
2014-02-04
Expiration Date
Abstract
A matrix material comprising a pharmaceutical composition printed on the surface is described. In one embodiment the pharmaceutical composition comprises thrombin. A method for making the matrix material with a pharmaceutical composition printed on the surface is also described. The matrix material can be used for promotion of hemostasis and/or wound healing. A kit-of-parts comprising a matrix with a pharmaceutical composition and a container with a peelable lid is described.
Core Innovation
The disclosed invention provides a hemostatic matrix material having a surface and a plurality of open and interconnected cells, where the matrix material comprises gelatine or collagen. The surface comprises at least one pharmaceutical composition printed onto the surface in individual and discrete locations, and the printed pharmaceutical composition comprises one or more hemostatic agents.
The pharmaceutical composition is printed as individual and discrete locations on the matrix surface, including embodiments in which thrombin is printed on a gelatine or collagen matrix. The surface-accessible printed locations support uniform distribution and reduction of waste relative to spraying, while maintaining the physical character of the matrix surface.
The disclosure also describes spatially precise droplets on the matrix surface and multi-composition printing where two or more different pharmaceutical compositions are printed in alternating discrete positions. The document associates the printing behavior with rapid evaporation without swelling, and it includes kit embodiments with a storage container and a peelable lid.
Claims Coverage
The independent claims are directed to three features: a hemostatic matrix of gelatine or collagen with open and interconnected cells, a pharmaceutical composition printed onto the surface in individual and discrete locations, and methods for promoting wound healing or promoting hemostasis.
Hemostatic matrix with open and interconnected cells
A hemostatic matrix material comprising a surface and a plurality of open and interconnected cells, wherein the matrix material comprises gelatine or collagen.
Printed pharmaceutical composition in discrete locations
The surface comprises at least one pharmaceutical composition printed onto the surface in individual and discrete locations.
Printed pharmaceutical composition contains hemostatic agents
The pharmaceutical composition comprises one or more hemostatic agents.
Apply matrix to a wound to promote wound healing
A method for promoting wound healing comprising applying to a wound a hemostatic matrix material comprising a surface and a plurality of open and interconnected cells, wherein the matrix material comprises gelatine or collagen, and wherein the surface comprises at least one pharmaceutical composition printed onto the surface in individual and discrete locations, the pharmaceutical composition comprising one or more hemostatic agents.
Apply matrix to a bleeding wound to promote hemostasis
A method for promoting hemostasis comprising applying to a bleeding wound a hemostatic matrix material comprising a surface and a plurality of open and interconnected cells, wherein the matrix material comprises gelatine or collagen, and wherein the surface comprises at least one pharmaceutical composition printed onto the surface in individual and discrete locations, the pharmaceutical composition comprising one or more hemostatic agents.
The claims center on a gelatine or collagen hemostatic matrix with open and interconnected cells, a pharmaceutical composition printed on the matrix surface in individual and discrete locations, and application of that matrix to a wound for wound healing or to a bleeding wound for hemostasis.
Stated Advantages
Uniform distribution of the pharmaceutical composition and reduction of waste relative to spraying.
Rapid evaporation without swelling.
The printed thrombin-only matrix is described as surprisingly sticky for dry use.
Promoting wound healing in an individual in need thereof.
Promoting hemostasis in an individual in need thereof.
Documented Applications
Use of the hemostatic matrix material to promote wound healing by applying it to a wound.
Use of the hemostatic matrix material to promote hemostasis by applying it to a bleeding wound.
Comparative evaluation in a pig spleen model.
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