Hemostatic agent and method
Inventors
Roberts, Keith A. • Burban, John Henry • Zia, Majid • Spearman, Michael R.
Assignees
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Publication Number
US-8623842-B2
Publication Date
2014-01-07
Expiration Date
Abstract
One aspect of the invention is a method of treating a wound to clot blood. A sponge material is applied to the wound. The sponge comprises a starch having hemostatic properties and at least one binding agent. The sponge may further comprise a porous, flexible material.
Core Innovation
The document relates to a hemostatic sponge/bandage system for treating bleeding wounds. The system includes a starch having hemostatic properties, specifically modified/cross-linked pregelatinized potato starch and/or amylopectin, including modified pregelatinized amylopectin. A binding agent is used with the starch-based hemostatic agent, and the system can optionally include a porous flexible material.
In addition to the starch and binding agent, the document lists optional components that can be present in the hemostatic sponge/bandage system. These optional components include binding agents such as HPMC/HPC and polyols, and optional clotting accelerators including calcium salts, prothrombin, and vitamin K. The document also lists optional medications including antibacterials, antifungals, and polyglucans.
The system is presented as a wound-contact hemostatic layer arranged with a bandage. Embodiments described include adhesive tabs pressing a wound-contact hemostatic layer, arrangements that include a plunger pressure feature, and embodiments with removable covers to expose the hemostatic agent while reducing scab disruption. The document further describes water absorption behavior using a viscosity/water-absorption experiment and provides example formulation ranges using starch and binder weight ratios.
Claims Coverage
Independent inventive coverage is provided by one independent method claim featuring a single core inventive feature: applying particles of a non-porous pregelatinized potato starch to a bleeding wound to clot blood.
Applying non-porous pregelatinized potato starch particles to clot blood
A method of treating a wound to clot blood comprising applying particles of a non-porous pregelatinized potato starch to a bleeding wound.
The independent claim is directed to clotting blood in a wound by applying non-porous pregelatinized potato starch particles, with dependent claim refinements covering delivery arrangements using bandages and adhesives, specific particle diameter ranges, and optional selection of additional components such as hemostatic agents, clotting accelerators, and medications from named lists.
Stated Advantages
Easier handling than powders, particularly in difficult body locations.
Improved flexibility without cracking.
Improved clot formation via water absorption.
Documented Applications
Treating bleeding wounds by clotting blood using a hemostatic sponge/bandage system.
Use in deep wounds as part of the described application context.
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