Method and device for drug delivery
Inventors
Pesach, Benny • Bitton, Gabriel • Weiss, Ram • Nagar, Ron
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-8622991-B2
Publication Date
2014-01-07
Expiration Date
Abstract
Systems, devices and methods for delivery of a chemical substance to the body of the patient are provided. Such embodiments may include an infusion catheter configured to be inserted into tissue, a catheter securing element configured to be adhered to the skin of the patient and further configured to secure the infusion catheter to the skin, a drug delivery pump configured to infuse a drug into the infusion catheter for delivery to a drug infused region on the body of the patient, and a treatment element configured to apply a treatment to the drug infused region to improve pharmacodynamics of the drug during a period of delivery of the drug to the patient.
Core Innovation
The described invention provides a device for delivering a therapeutic substance into a patient’s body using an infusion catheter inserted into bodily tissue at an insertion site to deliver the therapeutic substance to an infused region that includes a volume of bodily tissue surrounding the insertion site. A catheter securing element is adhered to the skin of the patient to secure the infusion catheter to the skin. The device includes a housing with a substance delivery device for infusing the therapeutic substance into the infusion catheter, and a sensor built into the housing configured to detect infusion of the therapeutic substance.
A treatment element is configured to apply a treatment in a vicinity of the infused region to modify a pharmacokinetic and/or pharmacodynamic profile of the therapeutic substance. A controller unit communicates with the treatment element and initiates application of the treatment by the treatment element upon detecting beginning of the infusion of the therapeutic substance. The treatment is applied locally near the infused region, coordinated with the detected start of infusion, to improve or stabilize pharmacokinetic and pharmacodynamic performance and reduce variability.
The document further describes that the treatment may include heating, cooling, temperature control, vibration, suction or massage, acoustic stimulation or ultrasound, and electromagnetic radiation such as optical, IR, RF, and microwave, with optional infusion of additional substances to modify the pharmacokinetic and pharmacodynamic profile. The described systems include architectures where disposable or reusable components are used, and where sensor-driven or pump-linked detection of infusion start triggers the treatment.
Claims Coverage
The dataset contains two independent claims (one device claim and one method claim). Across these independent claims, the core inventive coverage centers on coordinating a localized treatment near an infused region with detected beginning of infusion using a sensor-triggered controller to modify pharmacokinetic and/or pharmacodynamic profiles.
Infusion catheter delivering to an infused region with sensor-detected infusion start coordination
An infusion catheter inserted into bodily tissue at an insertion site delivers the therapeutic substance to an infused region including a volume of bodily tissue surrounding the insertion site, and a sensor built into the housing is configured to detect infusion.
Catheter securing element adhered to skin
A catheter securing element adhered to the skin of the patient secures the infusion catheter to the skin of the patient.
Housing with substance delivery device and controller-triggered localized treatment near infused region
A housing includes a substance delivery device for infusing the therapeutic substance into the infusion catheter, and includes a controller unit in communication with a treatment element configured to apply a treatment in a vicinity of the infused region; the controller initiates application of the treatment upon detecting beginning of the infusion of the therapeutic substance to modify a pharmacokinetic and/or pharmacodynamic profile.
Method steps: adhering, inserting, infusing, sensor-detected treatment initiation, and pharmacokinetic/pharmacodynamic modification
A method providing a device with an infusion catheter, a catheter securing element, a housing including a substance delivery device and a sensor to detect infusion, and a treatment element with a controller; adhering the catheter securing element to the skin, inserting the infusion catheter into bodily tissue at an insertion site, infusing the therapeutic substance into the infusion catheter, delivering the therapeutic substance to an infused region, initiating application of the treatment upon detecting beginning of infusion, applying the treatment in a vicinity of the infused region, and modifying a pharmacokinetic and/or pharmacodynamic profile of the infused therapeutic substance.
Both independent claims require delivering a therapeutic substance via an infusion catheter to an infused region, using a sensor to detect infusion beginning, a controller that initiates a treatment element applying treatment in the vicinity of the infused region upon detected infusion start, and modifying the pharmacokinetic and/or pharmacodynamic profile of the infused therapeutic substance.
Stated Advantages
Modifies a pharmacokinetic and/or pharmacodynamic profile of the therapeutic substance.
Improve or stabilize pharmacokinetic and/or pharmacodynamic performance.
Reduce variability.
Improve robustness and reduce hyper- and hypoglycemic events.
Documented Applications
Subcutaneous catheter-based drug delivery in a patient, including localized tissue treatment near an infused region during infusion to improve pharmacokinetic/pharmacodynamic performance.
Insulin delivery, including long-period/basal/bolus delivery concepts, with localized heating or other tissue treatments coordinated to infusion start.
Closed-loop “artificial pancreas” concepts using sensor feedback together with tissue stimulation/calibration to improve robustness and reduce hyper- and hypoglycemic events.
Implantable drug delivery systems and neural stimulation/calibration protocols with feedback control based on tissue response.
Interested in licensing this patent?