Resuscitation fluid
Inventors
Assignees
Publication Number
US-8569236-B2
Publication Date
2013-10-29
Expiration Date
2028-12-16
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Abstract
A method for treating conditions related to lack of blood supply with a lipid based resuscitation fluid is disclosed. The resuscitation fluid contains a lipid component and an aqueous carrier. The lipid component forms an emulsion with the aqueous carrier. The resuscitation fluid can be used to increase the blood pressure and to carry oxygen to tissues. The resuscitation fluid can also be used for preserving the biological integrity of donor organs for transplantation.
Core Innovation
The invention discloses a method and composition for treating conditions related to lack of blood supply using a lipid based resuscitation fluid. The resuscitation fluid comprises a lipid component and an aqueous carrier, with the lipid component forming an emulsion in the form of micelles that have a polar outer surface and a hydrophobic inner space. This composition is designed to increase blood pressure and serve as an oxygen carrier to body tissues.
The patent addresses the problem that currently employed blood substitutes such as perfluorocarbons and hemoglobin-based carriers are expensive, complex to purify, and associated with safety risks like toxicity and short shelf-life. Volume expanders alone do not carry oxygen, and existing blood substitutes have significant drawbacks for emergency or broad use situations.
The disclosed lipid-based emulsion is also described as useful in organ transplantation, where it can preserve the biological integrity of donor organs by acting as a perfusion fluid. The invention includes a resuscitation kit comprising the lipid-based fluid and an oxygenation device to load oxygen into the fluid immediately prior to application.
Claims Coverage
There are two independent claims in the patent, each describing inventive features related to a resuscitation kit using a lipid based resuscitation fluid and associated oxygenation device.
Resuscitation kit with lipid based resuscitation fluid and oxygenation device
A resuscitation kit comprising: - A lipid based resuscitation fluid that includes a lipid component and an aqueous carrier, wherein the lipid component forms an emulsion with the aqueous carrier in the form of lipid micelles with a polar outer surface and an inner hydrophobic space. - The resuscitation fluid is configured for carrying oxygen to tissues. - An oxygenation device adapted for oxygenating the resuscitation fluid immediately prior to application.
Resuscitation kit with oxygenated lipid based resuscitation fluid and re-oxygenation device
A resuscitation kit comprising: - An oxygenated lipid based resuscitation fluid with a lipid component and an aqueous carrier, where the lipid component forms an emulsion as lipid micelles with a polar outer surface and an inner hydrophobic space, and is used to carry oxygen to tissues. - An oxygenation device adapted for re-oxygenating the resuscitation fluid immediately prior to application.
The inventive features are focused on a kit comprised of a lipid-based resuscitation fluid able to form micelles for oxygen transport and an associated device for oxygenating or re-oxygenating the fluid before administration.
Stated Advantages
The lipid based resuscitation fluid is lower in cost compared to current blood substitutes.
It functions both as a volume expander and an oxygen carrier.
The lipid emulsion is effective at increasing blood pressure and carrying oxygen to tissues.
The resuscitation fluid can be oxygenated easily prior to administration.
The invention avoids the need for expensive and toxic perfluorocarbon or hemoglobin-based compositions.
Documented Applications
Treatment of conditions related to lack of blood supply, such as hypovolemia, ischemia, hemodilution, trauma, septic shock, cancer, anemia, cardioplegia, and hypoxia.
Use as a resuscitation fluid for increasing blood pressure and carrying oxygen to tissues in cases of severe blood loss.
Preservation of the biological integrity of donor organs for transplantation by perfusing the organ with the resuscitation fluid.
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