Apparatus and method for identifying myocardial ischemia using analysis of high frequency QRS potentials
Inventors
Toledo, Eran • Beker, Amir • Bregman-Amitai, Orna
Assignees
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Publication Number
US-8538510-B2
Publication Date
2013-09-17
Expiration Date
Abstract
Detecting cardiac ischemia by detecting local changes in high frequency ECG parameters. Local changes may be, for example, local reduction in RMS of high frequency components, for example, during a stress test.
Core Innovation
The invention provides a method for analyzing ECG signals in which a computer determines a value of at least one time-varying parameter of a high frequency band of the ECG signal. The computer detects an instant variation as a change in the parameter value compared to the parameter value at a short time before and generates an alert responsive to a decision algorithm comprising a set of rules that combine the instant variation and a physiological analysis of a low-frequency component.
The invention also describes detecting an ischemic event by scanning a high frequency band of an ECG signal collected from a plurality of heartbeats. In parallel, the computer performs a physiological analysis of a low-frequency component of the ECG signal, and the decision algorithm comprising a set of rules identifies the combination as indicative of a potential ischemic event.
The invention further provides apparatus that implements the same core approach. The apparatus includes an input for an ECG signal, a high-frequency band extractor, a filter configured to analyze the high-frequency band and detect an instant variation, a processor configured to analyze low frequency components of the ECG signal to produce at least one physiological consideration, and an output generating an output signal responsive to the decision algorithm.
Claims Coverage
The independent claims are directed to three inventive features: an ischemia-indicating alert based on a rule-based combination of high-frequency instant variation and low-frequency physiological analysis, detection of a potential ischemic event using the same combination, and an apparatus implementing the same functional blocks.
Instant high-frequency time-varying parameter variation for ischemia alerting
A method for analyzing ECG signals where a computer determines the value of at least one time-varying parameter of a high frequency band and detects an instant variation defined as a change in the parameter value compared to the parameter value at a short time before.
Rule-based combination with low-frequency physiological analysis
A method where a computer generates an alert responsive to a decision algorithm comprising a set of rules involving a combination of the instant variation and a physiological analysis of a low-frequency component of the ECG signal, producing at least one physiological consideration.
Ischemia-indicating alert responsive to decision algorithm rules
The method where the alert comprises indicating ischemia based on the decision algorithm combining the instant variation and the physiological consideration.
High-frequency band scan across plurality of heartbeats for potential ischemic event detection
A method of detecting an ischemic event in which a computer scans a high frequency band of an ECG signal collected from a plurality of heartbeats to detect an instant variation in a value of at least one time-varying parameter compared to the parameter value at a short time before.
Low-frequency component physiological analysis for event identification
A method where a computer performs a physiological analysis of a low-frequency component of the ECG signal.
Rules-based identification of potential ischemic event using combined change and analysis
A method where a computer identifies a combination of the change and the analysis as being indicative of a potential ischemic event responsive to a decision algorithm comprising a set of rules.
ECG apparatus with high-frequency band extractor and instant variation filter
An apparatus for ECG signal analysis comprising an input for an ECG signal, a high-frequency band extractor extracting a high frequency band, and a filter configured to analyze the high-frequency band and detect an instant variation defined as a change versus the parameter value at a short time before.
Processor producing physiological considerations from low-frequency components
An apparatus comprising a processor configured to analyze low frequency components of the ECG signal, producing at least one physiological consideration.
Output generating an output signal responsive to rules combining instant variation and low-frequency analysis
An apparatus where an output generates an output signal responsive to a decision algorithm comprising a set of rules involving a combination of the instant variation and the analysis of the low frequency components.
Across the independent claims, the inventive concept centers on detecting an instant variation of a time-varying parameter in a high-frequency band relative to a short time before value, performing physiological analysis on low-frequency ECG components to produce physiological considerations, and combining both within a decision algorithm comprising a set of rules to indicate ischemia or identify a potential ischemic event.
Stated Advantages
Improved diagnostic sensitivity/specificity versus conventional ST-T analysis in multiple patient cohorts.
Documented Applications
Myocardial ischemia detection using analysis of high-frequency ECG QRS potentials during stress testing.
Detection of a potential ischemic event using an ECG signal collected from a plurality of heartbeats.
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