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Publication Number
US-8470887-B2
Publication Date
2013-06-25
Expiration Date
Abstract
Provided, among other things, is a delivery module for a non-greasy, water-based urea composition comprising: an aerosol delivery device; within the aerosol delivery device, the urea composition comprising 20% or more urea by weight, non-greasy lipophilic component(s), and a frothing agent, the urea composition having a viscosity low enough to support aerosol delivery, and the urea composition effective to form a foam upon propellant-driven aerosol delivery; and within the aerosol delivery device, a propellant.
Core Innovation
The invention relates to a delivery module and a urea foam-forming formulation for dermatologic use. The formulation is described as a non-greasy, water-based aerosol composition that generates foam when delivered, and the delivery is propellant-driven to apply the urea formulation to skin using foam delivery.
The composition includes urea in a specified range and one or more carboxylic acid containing lipophilic components. A titrant is included in an amount such that at least a portion of the carboxylic acid containing lipophilic components are in ionized form, and high urea destabilizes water-based systems unless specific formulation parameters are met.
Foam formation is supported by the inclusion of a frothing agent, and optional components include hydrophilic polymers, humectants, soothing agents, and an emollient. Topical dermatologic indications explicitly described include psoriasis and hyperkeratotic conditions, and example compositions are provided with urea, a carboxylic-acid-containing lipophilic component, a titrant, a hydrophilic polymer, a soothing agent, and other optional components.
Claims Coverage
The partial content provided identifies one independent claim. The independent claim covers a non-greasy, water-based foamable urea composition defined by three core composition elements: urea level, carboxylic-acid-containing lipophilic components, and a titrant that ionizes at least a portion of the lipophilic components. Dependent claims refine the titrant identity, specify additional optional ingredients, narrow the lipophilic component to a specific fatty acid, and include an application/treatment claim to specified skin conditions.
Non-greasy, water-based foamable urea composition with ionized lipophilic carboxylic-acid component
A non-greasy, water-based foamable urea composition comprising urea 20-50% by weight; one or more carboxylic acid containing lipophilic components; and a titrant in an amount such that at least a portion of the one or more carboxylic acid containing lipophilic components are in ionized form.
The core coverage is the combination of urea at 20-50% by weight in a non-greasy water-based foamable composition with carboxylic-acid-containing lipophilic components that are at least partially converted to an ionized form by a titrant.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Treatment of one or more indications of dermatitis, psoriasis, zerosis, ichthyosis, ecezema, keratosis, keratoderma, dry and rough skin, corns, calluses, damaged or ingrown and devitalized nails by applying the composition to a patient’s skin.
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