Cerebrospinal fluid purification system
Inventors
Lad, Shivanand • Mobley, William C. • Nikolich, Karoly • Saul, Thomas
Assignees
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Publication Number
US-8435204-B2
Publication Date
2013-05-07
Expiration Date
Abstract
The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. A multilumen flow path allows exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.
Core Innovation
A method for ameliorating a symptom of cerebral vasospasm includes selecting a patient having the symptom of cerebral vasospasm and removing cerebrospinal fluid from a first location in a lumbar cerebrospinal fluid space of the patient. The removed cerebrospinal fluid is conditioned at a flow rate by removing at least one of erythrocytes, hemoglobin, oxyhemoglobin and endothelin from the removed cerebrospinal fluid.
The conditioned cerebrospinal fluid is returned to the patient at a second location in a cervical cerebrospinal fluid space or ventricle of the patient. The cerebrospinal fluid is returned at substantially the same flow rate at which it is removed, while the removing and returning steps are performed concurrently using a catheter during at least a portion of a conditioning treatment.
The concurrent removing and returning is performed using a catheter having a first lumen with a first proximal port at the first location and a second lumen having a second distal port at the second location. This enables concurrent removal and return during the conditioning treatment while conditioning includes removing erythrocytes, hemoglobin, oxyhemoglobin and endothelin.
Claims Coverage
The document includes one independent claim, directed to a concurrently performed removal/conditioning/return method for ameliorating cerebral vasospasm. The independent claim contains four inventive features covering patient selection and lumbar removal, conditioning by removal of specified components, concurrent dual-lumen catheter delivery with spatially separated ports, and substantially the same flow rate during return.
Concurrent lumbar removal and cervical or ventricle return for cerebral vasospasm
Conditioning removed cerebrospinal fluid from a lumbar cerebrospinal fluid space and returning the conditioned cerebrospinal fluid to a cervical cerebrospinal fluid space or ventricle while ameliorating a symptom of cerebral vasospasm.
Conditioning by removing erythrocytes, hemoglobin, oxyhemoglobin, and endothelin
Conditioning the cerebrospinal fluid at a flow rate by removing at least one of erythrocytes, hemoglobin, oxyhemoglobin and endothelin from the removed cerebrospinal fluid.
Substantially same flow rate concurrent catheter operation
Returning the conditioned cerebrospinal fluid at substantially the same flow rate at which it is removed, wherein the removing and returning steps are performed concurrently during at least a portion of a conditioning treatment.
Dual-lumen catheter with spatially separated ports
Performing removing and returning concurrently using a catheter having a first lumen with a first proximal port at the first location and a second lumen having a second distal port at the second location during at least a portion of a conditioning treatment.
Overall, the independent claim is centered on concurrent dual-lumen catheter removal, conditioning, and return of cerebrospinal fluid for cerebral vasospasm, with conditioning defined by removal of at least one of erythrocytes, hemoglobin, oxyhemoglobin and endothelin and return at substantially the same flow rate to a cervical cerebrospinal fluid space or ventricle.
Stated Advantages
Ameliorating a symptom of cerebral vasospasm.
Documented Applications
Ameliorating a symptom of cerebral vasospasm in a patient by removing cerebrospinal fluid from a lumbar space, conditioning it by removing erythrocytes, hemoglobin, oxyhemoglobin, and endothelin, and returning it to a cervical space or ventricle with substantially the same flow rate using a catheter.
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