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Publication Number
US-8394494-B2
Publication Date
2013-03-12
Expiration Date
Abstract
A new substrate makes it possible to modify surface properties relating to antimicrobial properties. Said substrate has an electron donating surface, characterized in having metal particles on said surface, said metal particles comprising palladium and at least one metal chosen from gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of said metal particles is from about 0.001 to about 8 μg/cm2. The substrate is suggested for different uses, such as for modifying the hydrophobicity, protein adsorption, adhesion of bacteria, as well as preventing bacterial transmission and in particular preventing nosocomial infections.
Core Innovation
The invention relates to an antimicrobial substrate having an electron donating surface and palladium-containing metal particles deposited on the surface. The metal particles comprise palladium and at least one non-palladium metal selected from gold, ruthenium, rhodium, osmium, iridium, and platinum, and are deposited from a suspension at an amount of about 0.001 to about 8 μg/cm² on the electron donating surface.
The metal particles are provided as distributed particles or clusters on the surface, and the metal particles do not form a covering layer. The particles have an average size of about 100 to about 10,000 Å, and the described uniform distribution and non-covering layer deposition enable controlled and repeatable modification of surface properties.
The invention is directed to changing surface properties such as hydrophobicity, protein adsorption, and bacterial adhesion. The resulting antimicrobial substrate is used to delay colonization and prevent bacterial growth and bacterial transmission, and the document particularly addresses prevention of nosocomial infections.
The disclosed substrate and object types include polymers, metals, glass, medical devices, disposable articles, dental devices, and dental implants. The document further describes measurement approaches for surface modification and adsorption, and provides experimental examples showing reduced bacterial growth and altered adhesion behavior on treated surfaces.
Claims Coverage
The independent claim is directed to reducing or preventing bacterial growth on a substrate by depositing palladium-containing metal particles on an electron donating surface under specific loading, composition, particle size, and non-covering-layer distribution conditions. A principal refinement set constrains quantitative ranges for metal loading and particle size, defines palladium-to-other-metal weight ratios, and optionally narrows the non-palladium metal selection and adds contacting with bacteria.
Electron donating surface on a substrate
Providing a substrate base comprising an electron donating surface.
Palladium-containing metal particles deposited from suspension
Depositing metal particles from a suspension of metal particles at an amount of about 0.001 to about 8 μg/cm² on the electron donating surface; wherein the metal particles comprise palladium and at least one non-palladium metal selected from gold, ruthenium, rhodium, osmium, iridium, and platinum.
Distributed particles or clusters that do not form a covering layer
Having the metal particles distributed particles or clusters on the surface, wherein the metal particles do not form a covering layer.
Controlled particle size
Having metal particles with an average size of about 100 to about 10,000 Å.
Optional narrowed loading range
The amount of metal particles on the electron donating surface is from about 0.01 to about 4 μg/cm².
Optional palladium-to-other-metal weight ratio
Characterized by a specified weight ratio of palladium to the at least one other selected metal (gold, ruthenium, rhodium, osmium, iridium, or platinum) in metal particles, within a defined range.
Optional constrained particle size interval
Metal particles having average sizes of about 100 to about 600 Å.
Optional selection of gold as the non-palladium metal
The at least one metal is gold.
Optional contacting the treated substrate with bacteria
Bringing a substrate with deposited metal particles into contact with bacteria.
Across the independent claim and refinements, the coverage centers on an electron donating surface that receives palladium-containing metal particles deposited at defined surface loadings, as distributed particles or clusters that do not form a covering layer, with controlled particle size, and optionally with a defined palladium-to-other-metal weight ratio, gold as the non-palladium metal, and contacting the treated substrate with bacteria.
Stated Advantages
Reduces or prevents bacterial growth on a substrate.
Delays colonization.
Prevents bacterial transmission.
Prevents nosocomial infections.
Enables controlled and repeatable modification of surface properties including hydrophobicity, protein adsorption, and bacterial adhesion.
Documented Applications
Medical devices and disposable articles used to prevent bacterial growth and bacterial transmission, including prevention of nosocomial infections.
Dental devices and dental implants used to prevent colonization and bacterial adhesion.
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