Resuscitation fluid
Inventors
Assignees
Publication Number
US-8367613-B2
Publication Date
2013-02-05
Expiration Date
2028-12-16
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Abstract
A method for treating conditions related to lack of blood supply with a lipid based resuscitation fluid is disclosed. The resuscitation fluid contains a lipid component and an aqueous carrier. The lipid component forms an emulsion with the aqueous carrier. The resuscitation fluid can be used to increase the blood pressure and to carry oxygen to tissues. The resuscitation fluid can also be used for preserving the biological integrity of donor organs for transplantation.
Core Innovation
The invention discloses a method and composition for treating conditions related to lack of blood supply using a lipid based resuscitation fluid. This resuscitation fluid contains a lipid component and an aqueous carrier, which together form an emulsion where the lipid forms micelles with a polar outer surface and a hydrophobic inner space. The resuscitation fluid is capable of increasing blood pressure and delivering oxygen to tissues.
Conventional approaches to blood substitution utilize perfluorocarbons or modified hemoglobins, both of which are costly and present toxicity or stability challenges. Perfluorocarbons require complex purification, and hemoglobin-based products have a short shelf-life and risk renal toxicity. Therefore, there remains a need for a lower-cost resuscitation fluid that expands volume and provides oxygen-carrying capacity similar to blood substitutes.
The disclosed lipid based resuscitation fluid can also be used for preserving the biological integrity of donor organs for transplantation. In addition to the lipid emulsion and aqueous carrier, the fluid can contain buffering agents, oncotic agents, and other additives, and may be provided in kit form with an oxygenation device for immediate preparation and use.
Claims Coverage
There are two independent claims, each introducing a main inventive feature regarding the composition of a lipid based resuscitation fluid and its use in organ preservation.
Lipid based resuscitation fluid composition
A resuscitation fluid comprising: - An oxygenated lipid emulsion, which includes a lipid component and an aqueous carrier. - A buffering agent. - The lipid component forms the emulsion with the aqueous carrier in the form of lipid micelles with a polar outer surface and an inner hydrophobic space.
Method for preserving organ biological integrity
A method involving perfusing an organ of a mammalian donor organism with an effective amount of a lipid based resuscitation fluid according to the specified composition: - The fluid includes an oxygenated lipid emulsion and a buffering agent, where the lipid component forms an emulsion with a polar outer surface and hydrophobic core.
The inventive features cover both the novel composition of a lipid based resuscitation fluid with oxygen-carrying capacity and the method of using this fluid to preserve the biological integrity of donor organs.
Stated Advantages
The resuscitation fluid serves as a low-cost alternative to existing blood substitutes while providing both volume expansion and oxygen-carrying capacity.
The lipid based resuscitation fluid is capable of increasing blood pressure and carrying oxygen to tissues.
The fluid can be used to preserve the biological integrity of donor organs for transplantation.
Documented Applications
Treating conditions related to lack of blood supply, including hypovolemia, ischemia, hemodilution, trauma, septic shock, cancer, anemia, cardioplegia, and hypoxia.
Use as a blood volume expander and oxygen carrier for the treatment of severe hemorrhagic shock.
Preserving the biological integrity of organs of a mammalian donor organism for transplantation by perfusing the organ with the resuscitation fluid.
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