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Assignees
Cambridge Medical Technologies LLC
Cambridge Medical TechnologiesCambridge Medical Technologies (CMT) is pioneering a transformative leap in combat casualty and critical care medicine with its advanced biosensor platform. Originally founded on research funded by DARPA, the Army Research Office (ARO), and Walter Reed Army Institute of Research, CMT’s mission has been clear from the start: develop non-invasive, real-time monitoring of blood chemistry for soldiers in the field. Their breakthrough technology samples subcutaneous interstitial fluid (ISF) painlessly and analyzes it outside the body for key biomarkers—starting with glucose and lactate, and now expanding to include blood pH.
This innovation is especially critical in military medicine, where early detection of hemorrhagic shock, sepsis, and metabolic failure can mean the difference between life and death. Traditional vital signs like heart rate and blood pressure often fail to reveal the severity of internal injuries or compensated shock. CMT’s biosensor platform fills this gap by continuously tracking biochemical indicators that reflect tissue perfusion (lactate), acid-base status (pH/base deficit), and stress response (glucose). These metrics are widely recognized in both civilian and military clinical guidelines as essential for guiding resuscitation and predicting outcomes.
Unlike conventional blood tests that require invasive sampling and lab processing, CMT’s devices—such as the LabPatch and LabClasp—use a proprietary method to extract ISF through the skin without needles. Within seconds, they deliver accurate readings of lactate and glucose, with pH integration underway. This allows medics and clinicians to monitor trends in real time, enabling faster, more informed decisions during trauma care, sepsis management, and evacuation triage.
For combat medics operating in austere environments, this technology is a game-changer. A wearable patch could continuously stream vital biochemical data from a wounded soldier to a handheld device, alerting caregivers to rising lactate or falling pH before traditional signs deteriorate. In emergency departments and ICUs, the same platform could reduce reliance on repeated blood draws, improve response times, and enhance patient outcomes.
CMT’s work aligns directly with the goals of the Department of Defense’s Advanced Medical Monitor (AMM) initiative under the Medical Technology Enterprise Consortium (MTEC). As future combat operations are expected to produce mass casualties and strain medical resources, integrating biochemical monitoring into standard vital sign systems is no longer optional—it’s urgent. CMT’s technology offers a scalable, field-ready solution that brings ICU-level insight to the point of injury.
In summary, CMT is redefining how we monitor and manage shock and sepsis in both military and civilian care. By combining non-invasive ISF sampling with rapid, multi-analyte analysis, their platform empowers caregivers with the data they need—when and where they need it most.
COMPANY BACKGROUND:
EXECUTIVES:
Dr. John Currie, Inventor & Chief Science Officer,
Jack Jachmann, CEO,
¤ James Cooke, CFO.
FUNDING: $30M in investment.
GRANTS: 3 SBIR awards totaling $2M.
EXPERIENCE: 8 years of operation.
INTELLECTUAL PROPERTY: 14 US and international patents.
TEAM: 21 employees.
LOCATIONS: Maryland & California (US), United Kingdom, Japan.
MANUFACTURING: 2 contract chip manufacturers (US and Japan).
CLINICAL TRIALS: 3 hospital sites in Massachusetts, 1 in Minnesota, 1 in Colorado.
FOCUS AREAS: Emergency Medicine, Diabetes, Alcoholism & Addiction.
MARKET: We are one year away from launching our monitor product, which will initially support four analytes, with additional planned analytic capabilities employing the same platform.
Cambridge Medical Technologies (CMT) is pioneering a transformative leap in combat casualty and critical care medicine with its advanced biosensor platform. Originally founded on research funded by DARPA, the Army Research Office (ARO), and Walter Reed Army Institute of Research, CMT’s mission has been clear from the start: develop non-invasive, real-time monitoring of blood chemistry for soldiers in the field. Their breakthrough technology samples subcutaneous interstitial fluid (ISF) painlessly and analyzes it outside the body for key biomarkers—starting with glucose and lactate, and now expanding to include blood pH. This innovation is especially critical in military medicine, where early detection of hemorrhagic shock, sepsis, and metabolic failure can mean the difference between life and death. Traditional vital signs like heart rate and blood pressure often fail to reveal the severity of internal injuries or compensated shock. CMT’s biosensor platform fills this gap by continuously tracking biochemical indicators that reflect tissue perfusion (lactate), acid-base status (pH/base deficit), and stress response (glucose). These metrics are widely recognized in both civilian and military clinical guidelines as essential for guiding resuscitation and predicting outcomes. Unlike conventional blood tests that require invasive sampling and lab processing, CMT’s devices—such as the LabPatch and LabClasp—use a proprietary method to extract ISF through the skin without needles. Within seconds, they deliver accurate readings of lactate and glucose, with pH integration underway. This allows medics and clinicians to monitor trends in real time, enabling faster, more informed decisions during trauma care, sepsis management, and evacuation triage. For combat medics operating in austere environments, this technology is a game-changer. A wearable patch could continuously stream vital biochemical data from a wounded soldier to a handheld device, alerting caregivers to rising lactate or falling pH before traditional signs deteriorate. In emergency departments and ICUs, the same platform could reduce reliance on repeated blood draws, improve response times, and enhance patient outcomes. CMT’s work aligns directly with the goals of the Department of Defense’s Advanced Medical Monitor (AMM) initiative under the Medical Technology Enterprise Consortium (MTEC). As future combat operations are expected to produce mass casualties and strain medical resources, integrating biochemical monitoring into standard vital sign systems is no longer optional—it’s urgent. CMT’s technology offers a scalable, field-ready solution that brings ICU-level insight to the point of injury. In summary, CMT is redefining how we monitor and manage shock and sepsis in both military and civilian care. By combining non-invasive ISF sampling with rapid, multi-analyte analysis, their platform empowers caregivers with the data they need—when and where they need it most. COMPANY BACKGROUND: EXECUTIVES: Dr. John Currie, Inventor & Chief Science Officer, Jack Jachmann, CEO, ¤ James Cooke, CFO. FUNDING: $30M in investment. GRANTS: 3 SBIR awards totaling $2M. EXPERIENCE: 8 years of operation. INTELLECTUAL PROPERTY: 14 US and international patents. TEAM: 21 employees. LOCATIONS: Maryland & California (US), United Kingdom, Japan. MANUFACTURING: 2 contract chip manufacturers (US and Japan). CLINICAL TRIALS: 3 hospital sites in Massachusetts, 1 in Minnesota, 1 in Colorado. FOCUS AREAS: Emergency Medicine, Diabetes, Alcoholism & Addiction. MARKET: We are one year away from launching our monitor product, which will initially support four analytes, with additional planned analytic capabilities employing the same platform.
Abstract
The present invention generally relates to a system and method that co-locates in a small flexible, configurable system and multi-level substrate sampling, rapid analysis, bio-sample storage and delivery functions to be performed on living tissues or matter obtained from living organisms. The types of the sampling may include chemical, biochemical, biological, thermal, mechanical, electrical, magnetic and optical sampling. In general, the analysis performed at the point of sampling measures the sample taken and records its value. The bio-sample storage function encapsulates a small sample of analyte and preserves it for subsequent examination or analysis, either on the organism by the system or at a remote location by an independent analysis system. Once stored, the sample can provide a record of a biological state at the precise time of sampling. The delivery at the point of sampling can include chemical, biochemical, biological, thermal, mechanical, electrical, magnetic and optical stimuli.
Core Innovation
The present invention generally relates to a system and method that co-locates in a small flexible, configurable system multi-level substrate sampling, rapid analysis, bio-sample storage and delivery functions to be performed on living tissues or matter obtained from living organisms. The types of the sampling may include chemical, biochemical, biological, thermal, mechanical, electrical, magnetic and optical sampling, and the analysis performed at the point of sampling measures the sample taken and records its value.
The bio-sample storage function encapsulates a small sample of analyte and preserves it for subsequent examination or analysis, either on the organism by the system or at a remote location by an independent analysis system. The delivery at the point of sampling can include chemical, biochemical, biological, thermal, mechanical, electrical, magnetic and optical stimuli and the results of the measurements may provide a quantitative snapshot at the instant of sampling that can report a possible disease state and enable intervention.
The disposable sampling part of the system may be mechanically flexible and made of multiple thin layers so as to deform to take the shape of the tissue to be monitored and adhere to it while remaining minimally intrusive. The system and all of its constituent parts is configurable as to the positioning of the sampling on the organism, the number and variety of measurement targets, the type and invasiveness of sampling, the storage and modification of samples, and the frequency, redundancy, recording and reporting of individual measurements.
Claims Coverage
This section identifies four independent inventive features claimed in the patent.
Flexible sensor with micro-heater and electrodes
A sensor comprising: a flexible substrate; a micro-heater formed on the surface of the flexible substrate, wherein the micro-heater is configured to repeatedly generate a temperature sufficient to disrupt the stratum corneum without ablating the cells to obtain the biomolecule; a first pair of electrically conductive paths coupled to the micro-heater; a pair of electrodes supported by the flexible substrate and positioned proximate to the micro-heater, the pair of electrodes comprising a reference electrode and a working electrode being electrochemically activated and configured to react with the biomolecule; and a second pair of electrically conductive paths coupled to the reference electrode and the working electrode.
Sensor with external counter electrode
A sensor comprising: a flexible substrate; a micro-heater formed on the surface of the flexible substrate, wherein the micro-heater is configured to repeatedly generate a temperature sufficient to disrupt the stratum corneum without ablating the cells to obtain the biomolecule; a pair of electrodes supported by the flexible substrate, the pair of electrodes comprising a reference electrode and a working electrode being electrochemically activated and configured to react with the biomolecule; and an external counter electrode.
Cantilevered piezoelectric sensor with electrochemical electrodes
A sensor comprising: a flexible substrate comprising a cantilevered beam formed using a piezoelectric material, wherein the cantilevered beam is configured to measure a deformation of the sensor; and a pair of electrodes supported by the flexible substrate, the pair of electrodes comprising a reference electrode and a working electrode being electrochemically activated and configured to react with the biomolecule.
Piezoelectric deformation sensor with external counter electrode
A sensor comprising: a flexible substrate comprising a piezoelectric material configured to measure a deformation of the sensor; a pair of electrodes supported by the flexible substrate, the pair of electrodes comprising a reference electrode and a working electrode being electrochemically activated and configured to react with a biomolecule; and an external counter electrode.
The independent claims cover a flexible sensor architecture combining a surface micro-heater to disrupt the stratum corneum without ablating cells, electrochemically activated working and reference electrodes positioned proximate to the heater, options for external counter electrodes, and piezoelectric detection structures (including cantilevered beams) integrated on a flexible substrate.
Stated Advantages
Co-locates sampling, rapid analysis, bio-sample storage and delivery functions in a small flexible, configurable system.
Provides a quantitative snapshot at the instant of sampling and records values for possible disease-state reporting and intervention.
Minimally intrusive contact that deforms to the shape of tissue to be monitored and adheres to it.
Configurable positioning, number and variety of measurement targets, sampling types, storage and measurement frequency.
Encapsulates and preserves small analyte samples for subsequent on-device or remote analysis.
Documented Applications
Diabetes monitoring and treatment, including sensing of glucose and related analytes and release of drugs such as human insulin from stored cavities.
Resuscitative medicine, including monitoring and treatment in hemorrhagic shock, trauma, and burns.
Detection and treatment of pediatric jaundice through monitoring of bilirubin.
Monitoring of stamina, physical performance, fatigue, and alertness via glucose and lactate sensing and dissolved gas measurements.
Testing tissue viability, performing tissue biopsy analysis, and implant tissue monitoring for viability and functionality before and following surgery.
Early detection of diseases such as cancer and infectious diseases, and monitoring responses to treatment.
Detection and treatment of dental and oral conditions, including sampling of cheek, gum and crevicular fluids for bacteria, viruses, microbial film, inflammation and caries.
Monitoring obesity, diet, exercise, weight, body composition and related hormones and metabolites (e.g., leptin, ghrelin, insulin).
Monitoring cardio- and vascular functions and stroke-related markers, including cardiac biomarkers and inflammatory markers.
Drug discovery and development screening, pharmacokinetic studies, individual dosing, efficacy, safety, toxicity and clinical trials monitoring.
Detecting and treating infectious diseases including influenza, malaria, Dengue fever, HIV and tuberculosis using antibody and enzyme-based sensors and delivery cavities.
Neural interfacing for short-term or long-term interfacing such as prosthetic control and therapeutic response monitoring.
Monitoring animals, crops, water and food supplies for environmental biosecurity and contamination.
Monitoring for substance and drug use and abuse, including nicotine, cotinine, opiates, cocaine and alcohol metabolites.
Drug dosing clinics and individualized dosing management for drugs such as anti-coagulants.
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