Quick disconnect liquid chromatograph columns
Inventors
Assignees
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Publication Number
US-8318010-B2
Publication Date
2012-11-27
Expiration Date
Abstract
A chromatography column and method for use in a liquid chromatography process includes a telescoping chromatography and piston tubes, with the piston tube having a porous layer partially obstructing flow therethrough. A chromatography clamp is selectively movable between open and closed positions, and configured to extend substantially 360 degrees about the periphery of the chromatography tube when closed. The chromatography clamp is configured to releasably maintain the chromatography tube and piston tube in fluid communication with one another. In particular embodiments, the chromatography clamp includes a ledge extending at an oblique angle relative to the transverse direction, which is configured to cam the clamp towards the closed position upon application of greater than atmospheric pressure within the chromatography column.
Core Innovation
A chromatography column is provided for use in a liquid chromatography process. The column includes a chromatography tube and a piston tube having an outer diameter smaller than an inner diameter of the chromatography tube, and the piston tube has at least one porous layer partially obstructing flow through the piston tube.
At least one chromatography clamp is selectively movable between open and closed positions and, when closed, is configured to extend substantially 360 degrees about the periphery of the chromatography tube, while no single component of the chromatography clamp extends substantially 360 degrees. The chromatography clamp is configured to releasably maintain the chromatography tube and piston tube in fluid communication with one another.
The chromatography clamp includes a clamp ledge extending at an oblique angle relative to the transverse direction, and the clamp ledge is configured to engage a collar ledge to cam the clamp towards the closed position upon application of greater than atmospheric pressure within the column. A collar is configured to capture the piston tube and includes the collar ledge for the camming interaction.
Claims Coverage
The document provides two independent claims. The claims cover a chromatography column for liquid chromatography with a piston tube having a porous layer, a selectively movable clamp that provides substantially 360 degrees closure without any single clamp component extending substantially 360 degrees, and an oblique clamp ledge engaging a collar ledge to cam closure upon application of greater than atmospheric pressure.
Piston tube with porous layer partially obstructing flow
A piston tube having an outer diameter smaller than an inner diameter of said chromatography tube, wherein said piston tube has at least one porous layer partially obstructing flow through the piston tube.
Selectively movable clamp extending substantially 360 degrees without a single 360-degree component
At least one chromatography clamp being selectively movable between open and closed positions and configured to extend substantially 360 degrees about the periphery of said chromatography tube when closed, with no single component of said chromatography clamp extending substantially 360 degrees.
Oblique clamp ledge cammed closure under greater than atmospheric pressure
A chromatography clamp having a clamp ledge extending at an oblique angle relative to the transverse direction, configured to engage the collar ledge to cam the clamp towards the closed position upon application of greater than atmospheric pressure within the column.
Releasably maintaining fluid communication between chromatography tube and piston tube
Said chromatography clamp configured to releasably maintain said chromatography tube and piston tube in fluid communication with one another.
Collar configured to capture the piston tube and provide collar ledge
A collar configured to capture said piston tube and having a collar ledge.
Across the independent claims, the main inventive coverage centers on the piston tube with a porous layer, the selectively movable chromatography clamp providing substantially 360 degrees closure without any single component spanning substantially 360 degrees, and the oblique clamp ledge/collar ledge interaction that cams the clamp towards closure upon application of greater than atmospheric pressure. The clamp also releasably maintains fluid communication between the chromatography tube and the piston tube.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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