Substrate having an electron donating surface with metal particles comprising palladium on said surface
Inventors
Ohrlander, Mattias • SOEDERVALL BILLY, null • Södervall, Billy
Assignees
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Publication Number
US-8309216-B2
Publication Date
2012-11-13
Expiration Date
Abstract
The invention relates to a substrate with an electron donating surface, having metal particles on its surface, the metal particles including palladium and at least one metal selected from gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of the metal particles is from about 0.001 to about 8 μg/cm2. A method of manufacturing the substrate including the steps a) depositing metal particles from a suspension of metal particles onto the substrate, b) rising and c) drying.
Core Innovation
A substrate having an electron donating surface includes metal particles on the electron donating surface. The metal particles comprise palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum. The amount of the metal particles is from about 0.001 to about 8 μg/cm2, and the metal particles are distributed particles or distributed clusters on the electron donating surface.
The invention targets repeatable modification of surface properties relevant to biocompatibility and antimicrobial performance. The surface properties include hydrophobicity, protein adsorption, and bacterial adhesion and bacterial growth, as well as tissue ingrowth, complement activation, inflammatory response, and thrombogenicity, together with friction coefficient and surface hardness.
The documented disclosure includes manufacturing by depositing metal particles from a suspension onto the electron donating surface with rinsing and drying. The described objective is prevention of nosocomial infections, supported by measurements related to complement activation, platelet adhesion, cytokines and terminal complement, and cell responses.
Claims Coverage
The independent claim requires a substrate with an electron donating surface bearing distributed palladium-containing metal particles at a specified loading per area. The claim set emphasizes distribution as particles or distributed clusters and defines the amount of metal particles, with dependent claims adding composition ratio, particle size, substrate type, device integration, and property outcomes.
Electron donating surface with palladium-containing distributed metal particles
A substrate having an electron donating surface, wherein there are metal particles on said surface, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum.
Specified metal particle loading per unit area
The amount of said metal particles is from about 0.001 to about 8 μg/cm2.
Distributed particles or distributed clusters
The metal particles are distributed particles or distributed clusters on the electron donating surface.
Distributed metal particle loading sub-range
The substrate is characterized such that its metal particle amount is from about 0.01 to about 4 μg/cm2.
Palladium-to-non-palladium metal ratio
The substrate includes metal particles where the palladium-to-non-palladium metal ratio is about 0.01:99.99 to about 99.99:0.01.
Average particle size range
The substrate includes metal particles having an average size of about 10–2000 Å.
Gold included with palladium-containing metal particles
The substrate is characterized such that its metal particles, besides palladium, include gold.
Medical device integrating the substrate to modify biological and surface properties
Integrating a substrate into a medical device to impart one or more selected surface or biological properties, including modifying protein adsorption, bacterial adhesion, tissue ingrowth, complement activation, inflammatory response, blood clotting, and friction or hardness, or preventing bacterial growth, bacterial transmission, and nosocomial infections.
Across the independent claim and highlighted inventive features, the scope is defined by an electron donating surface bearing distributed palladium-containing metal particles, a defined per-area loading, and distribution as particles or distributed clusters. Dependent claims further narrow composition ratio, particle average size, explicitly include gold in at least one embodiment, and connect the substrate to medical device integration for listed property and antimicrobial/nosocomial-infection outcomes.
Stated Advantages
Prevention of nosocomial infections.
Prevention of bacterial growth and bacterial transmission.
Modification of protein adsorption, bacterial adhesion, and tissue ingrowth.
Modification of complement activation and inflammatory response.
Modification of blood clotting, friction coefficient, and surface hardness.
Documented Applications
Use of a medical device comprising the substrate to modify selected surface or biological properties, including protein adsorption, bacterial adhesion, tissue ingrowth, complement activation, inflammatory response, blood clotting, friction, and surface hardness, and to prevent bacterial growth, bacterial transmission, and nosocomial infections.
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