System, devices, and methods for detecting occlusions in a biological subject
Inventors
Boyden, Edward S. • Leuthardt, Eric C.
Assignees
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Publication Number
US-8280484-B2
Publication Date
2012-10-02
Expiration Date
Abstract
Systems, devices, and methods are described for detecting an embolus, thrombus, or a deep vein thrombus in a biological subject.
Core Innovation
The invention relates to an occlusion monitoring device for a biological subject under test. The device includes an interrogation energy emitter component and a sensor component configured to detect at least one of an emitted energy or a remitted energy.
Using the detected energy, the sensor component determines at least one spatial dependence and at least one temporal dependence associated with an occlusion in an artery, a blood clot formation in a blood vessel, an embolus, or a blood clot formation in a deep vein. The device predicts the onset of an obstruction in blood vessel and generates a first response indicative of at least one physical parameter associated with the spatial dependence and the temporal dependence of the occlusion, blood clot formation, embolus, or deep vein thrombus within the biological subject under test.
The determining of spatial and temporal dependence is based on comparison of the detected emitted energy or remitted energy with stored blood vessel spectral occlusion information. The stored information is provided as a data structure on one or more non-transitory computer-readable memory media and includes a spectral signature information section having at least one of embolus spectral information, arterial embolus spectral information, thrombus spectral information, deep vein thrombus spectral information, or blood component spectral information.
In further described aspects, the occlusion monitoring concepts include real-time spectral learning model updating and differential spectral measurements to isolate blood signals from detected spectral information. The stored and learned spectral signature data supports spectral clustering/learning protocols and model-based comparisons, including protocols such as fuzzy c-means, k-means, Gaussian mixtures, and expectations-maximization.
Claims Coverage
The independent claim coverage centers on an occlusion monitoring device with emitted or remitted energy detection, spatial and temporal dependence determination, prediction of obstruction onset, and a response based on comparison with blood vessel spectral occlusion information stored as a data structure. The dependent-claim coverage adds interrogation modality, spectral information content, clustering, probabilistic or modeling protocols, and heuristically determined parameters.
Occlusion monitoring device with interrogation emitter and energy sensor
An occlusion monitoring device includes an interrogation energy emitter component and a sensor component configured to detect at least one of an emitted energy or a remitted energy for determining spatial and temporal dependence associated with an occlusion in an artery, a blood clot formation in a blood vessel, an embolus, or a blood clot formation in a deep vein.
Spatial and temporal dependence determination for vascular occlusion events
A sensor component determines at least one spatial dependence and at least one temporal dependence associated with an occlusion, blood clot formation, embolus, or deep vein thrombus in the biological subject under test, based on comparison of the detected emitted energy or remitted energy and stored blood vessel spectral occlusion information.
Prediction of onset of blood vessel obstruction and physical-parameter response generation
The device predicts the onset of an obstruction in blood vessel and generates a first response indicative of at least one physical parameter associated with the spatial dependence and the temporal dependence of the occlusion event in the biological subject under test.
Data structure storing blood vessel spectral occlusion information with spectral signatures
One or more non-transitory computer-readable memory media having blood vessel spectral occlusion information configured as a data structure, including a spectral signature information section having at least one of embolus spectral information, arterial embolus spectral information, thrombus spectral information, deep vein thrombus spectral information, or blood component spectral information.
Comparison-based determination using spectral signature data structure
The sensor component includes one or more computing devices configured to determine the at least one spatial dependence and the at least one temporal dependence associated with the occlusion in the biological subject under test based on the comparison of the detected emitted energy or a remitted energy and the blood vessel spectral occlusion information configured as the data structure.
Ultrasonic interrogation energy emitter modality
The interrogation energy emitter component is configured to use an ultrasonic interrogation energy emitter to deliver ultrasonic interrogation energy to a region of a biological subject.
Spectral coefficient-related embolus spectral information
Embolus spectral information includes at least one of an embolus absorption value indicative of an embolus absorption coefficient, an embolus extinction value indicative of an embolus extinction coefficient, or an embolus scattering value indicative of an embolus scattering coefficient.
Specified spectral information clustering and probabilistic/modeling protocols
Determine blood vessel spectral occlusion information using spectral-information cluster performed with one or more specified clustering, probabilistic, or modeling protocols.
Heuristically determined parameters including threshold level or target parameter
Includes one or more heuristically determined parameters that comprise at least a threshold level or a target parameter.
The coverage centers on comparison-driven determination of spatial and temporal dependence from emitted or remitted energy using a memory-stored data structure of blood vessel spectral occlusion spectral signatures, enabling prediction of obstruction onset and generation of a response indicative of physical parameters. Dependent claims further narrow the interrogation modality and specify spectral-information clustering, coefficient-related spectral information, and heuristically determined threshold or target parameters.
Stated Advantages
Generates a first response indicative of at least one physical parameter associated with spatial dependence and temporal dependence of the occlusion event.
Predicts the onset of an obstruction in blood vessel.
Documented Applications
Occlusion monitoring in a biological subject under test for an occlusion in an artery, blood clot formation in a blood vessel, embolus, and blood clot formation in a deep vein.
Detection and characterization of spectral occlusion information for embolus, arterial embolus, thrombus, and deep vein thrombus, including blood component spectral information.
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