Biodegradable polymer scaffold and process for preparation thereof
Inventors
Panda, Amulya Kumar • Gopimohan, Rajmohan • Chakkunkal, Anish
Assignees
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Publication Number
US-8268342-B2
Publication Date
2012-09-18
Expiration Date
Abstract
The present invention relates to a process for preparation of a biodegradable polymer scaffold using biodegradable polymer, surfactant and alcohol. The biodegradable polymer scaffold obtained from the process disclosed is useful for tissue engineering, therapeutic compound delivery and/or wound dressing.
Core Innovation
The invention describes a process of preparation of a biodegradable polymer scaffold and a biodegradable polymer membrane useful for tissue engineering, therapeutic compound delivery and/or wound dressing. The process uses surfactant coated polymer particles, where the polymer comprising the particles is selected from poly-DL-lactide and polylactide co-glycolide. The particles are added to or spread on a mold.
In the process, the surfactant coated polymer particles are soaked with alcohol, and the soaking causes the fusion of the particles to form a scaffold or a membrane. After fusion, the process includes washing the above with water to obtain the polymer scaffold or the polymer membrane from the mold. The approach is framed as forming stable higher-order scaffold or membrane structures from surfactant-coated biodegradable polymer particles.
The disclosure further states that the process preserves polymer intrinsic properties including glass transition temperature, and maintains amorphous nature and polymer characteristics consistent with the starting biodegradable polymers. It also reports that the method can include encapsulation of therapeutic compounds while avoiding damaging encapsulated bioactive payloads.
Claims Coverage
The partial content provides four independent claim groupings covering biodegradable polymer scaffolds and biodegradable polymer membranes. Across these claims, the inventive features center on surfactant-coated biodegradable polymer particles, alcohol soaking that causes fusion, and water washing to obtain the scaffold or membrane from the mold.
Biodegradable polymer scaffold preparation using surfactant-coated poly-DL-lactide or polylactide co-glycolide particles in a mold
Adding surfactant coated polymer particles to a mold, wherein the polymer comprising the particles is selected from the group consisting of poly-DL-lactide and polylactide co-glycolide.
Alcohol soaking fusion to form a biodegradable polymer scaffold
Soaking said particles with alcohol, wherein soaking causes the fusion of said particles to form a scaffold.
Water washing to obtain a biodegradable polymer scaffold from the mold
Washing the above with water to obtain the polymer scaffold from the mold.
Biodegradable polymer membrane preparation using surfactant-coated poly-DL-lactide or polylactide co-glycolide particles on a mold
Spreading surfactant coated polymer particles on a mold, wherein the polymer comprising said particles is selected from the group consisting of poly-DL-lactide and polylactide co-glycolide.
Alcohol soaking fusion to form a biodegradable polymer membrane
Soaking said particles with alcohol, wherein soaking causes the fusion of said particles to form a membrane.
Water washing to obtain a biodegradable polymer membrane from the mold
Washing the above with water to obtain the polymer membrane from the mold.
Across the independent claims, the claimed scope repeatedly requires surfactant coated biodegradable polymer particles of poly-DL-lactide and/or polylactide co-glycolide, alcohol soaking that causes fusion into a scaffold or membrane, and washing with water to obtain the final scaffold or membrane from the mold.
Stated Advantages
Improved wound closure versus untreated controls, as reported in an animal wound-healing evaluation using a fused polylactide membrane.
Increased collagen content versus untreated controls, as reported in the animal wound-healing evaluation.
The process is described as converting surfactant-coated biodegradable polymer particles into stable higher-order scaffold or membrane structures.
The disclosure reports that encapsulated bioactive payloads are not damaged.
Documented Applications
Tissue engineering using the biodegradable polymer scaffold and biodegradable polymer membrane.
Therapeutic compound delivery using the biodegradable polymer scaffold and biodegradable polymer membrane.
Wound dressing using the biodegradable polymer scaffold and biodegradable polymer membrane.
Animal wound-healing evaluation using a fused polylactide membrane, showing improved wound closure and increased collagen content versus untreated controls.
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