Waveguide-based sensor

Inventors

Heideman, Rene Gerrit

Assignees

LioniX International BV

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Publication Number

US-8253933-B2

Patent

Publication Date

2012-08-28

Expiration Date


Abstract

A sensor for sensing a target chemical with high signal-to-noise ratio is disclosed. In some embodiments, the sensor comprises a sensing region that is optically coupled with an attenuation region. The sensing region receives optical stimulation that comprises light characterized by an excitation wavelength. In response to exposure to the target chemical, the sensing region fluoresces at a fluorescence wavelength. The attenuation region receives light from the fluorescing sensing region that includes light characterized by the fluorescence wavelength (i.e., signal) and light characterized by the excitation wavelength (i.e., noise). The attenuation region conveys the light to a detector that provides an electrical output signal based on the target chemical. While conveying the light, however, the attenuation region improves the signal-to-noise ratio by attenuating light characterized by the excitation wavelength more than light characterized by the fluorescence region.

Core Innovation

The invention describes a fluorescence chemical sensor that uses a first sensing region that comprises a first material and a first waveguide portion. The first material provides a fluorescence signal characterized by a fluorescence wavelength when exposed to a target chemical and light characterized by a first excitation wavelength. A corresponding attenuation region includes a second waveguide portion and a second material, where the second material has a first absorptivity at the excitation wavelength and a second absorptivity at the fluorescence wavelength, with the first absorptivity greater than the second absorptivity.

The attenuation region is dimensioned and arranged so that light propagating in the second waveguide portion evanescently couples with the second material, thereby enabling preferential attenuation of excitation-wavelength light relative to fluorescence-wavelength light. In a PLC-based implementation, the first surface waveguide on a substrate has a sensing region and an attenuation region, and the attenuation region receives light from the sensing region.

The attenuation region includes a second portion of the surface waveguide and a second material comprising a wavelength-selective absorbing dye configured with the stated excitation-versus-fluorescence absorptivity relationship. The disclosed sensor configurations further include structures in which the attenuation region is optically coupled to the wavelength-selective absorbing dye using shaped waveguide portions, and optionally include resonant elements and beam dump configurations.

The waveguide structures can be adapted to increase interaction, such as using spiral-shaped waveguides, and multi-sensor arrays can be provided to map chemical distribution across a substrate based on electrical output signals.

Claims Coverage

The document provides three independent claims. Across these, the central inventive concept is the use of a dimensioned attenuation region with wavelength-selective absorbing material and evanescent coupling that preferentially attenuates excitation-wavelength light more than fluorescence-wavelength light, in a waveguide or PLC sensor architecture.

Wavelength-selective attenuation via evanescently coupled waveguide portion

A sensor comprising a first sensing region that comprises a first material and a first waveguide portion, wherein the first material provides a first fluorescence signal characterized by a first fluorescence wavelength when exposed to a first target chemical and light characterized by a first excitation wavelength, and a first attenuation region comprising a second waveguide portion and a second material, wherein the second material has a first absorptivity at the first excitation wavelength and a second absorptivity at the first fluorescence wavelength, and wherein the first absorptivity is greater than the second absorptivity, wherein the first attenuation region is dimensioned and arranged such that light propagating in the second waveguide portion evanescently couples with the second material.

PLC-based surface waveguide with dye-selective excitation attenuation

A PLC-based sensor comprising a first surface waveguide disposed on a substrate, wherein a sensing region comprises a first portion of the first surface waveguide and comprises a first material that fluoresces at a fluorescence wavelength when exposed to a target chemical and light characterized by an excitation wavelength; and an attenuation region physically adapted to receive light from the sensing region, wherein the attenuation region comprises a second portion of the first surface waveguide and a second material comprising a wavelength-selective absorbing dye that has a first absorptivity for light characterized by the excitation wavelength and a second absorptivity for light characterized by the fluorescence wavelength, and wherein the first absorptivity is greater than the second absorptivity, wherein the attenuation region is dimensioned and arranged such that a light signal propagating in the second portion evanescently couples with the second material.

Sensing method with excitation-wavelength absorption from evanescent field

A method for sensing a target chemical, wherein the method comprises providing a first light signal from a first sensing region that includes a first waveguide portion, wherein the first light signal comprises light characterized by an excitation wavelength and a fluorescence signal characterized by a fluorescence wavelength, and wherein the fluorescence signal is based on the target chemical; receiving the first light signal at a first attenuation region comprising a second waveguide portion and a first material that absorbs light characterized by the excitation wavelength more than light characterized by the fluorescence wavelength, wherein the first attenuation region is dimensioned and arranged to enable a light signal propagating in the second waveguide portion to evanescently couple with the first material; and attenuating the first light signal in the first attenuation region by absorbing light characterized by the excitation wavelength from the evanescent field of the first light signal in the first material.

Across the independent claims, the sensor architecture combines a fluorescence-generating sensing region with an attenuation region containing wavelength-selective absorbing material. The attenuation region is dimensioned and arranged to achieve evanescent coupling between waveguide-propagating light and the absorbing material, with absorptivity constrained to be greater at the excitation wavelength than at the fluorescence wavelength, and the method claim attenuates the excitation component by absorption from the evanescent field.

Stated Advantages

Improves signal-to-noise ratio (SNR) by selectively suppressing excitation-wavelength noise more than fluorescence-wavelength signal.

Documented Applications

Waveguide/PLC fluorescence chemical sensor configurations, including multi-sensor arrays, for mapping chemical distribution across a substrate based on electrical signals.

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