Size-selective polymer system
Inventors
Young, Wei-Tai • Albright, Robert L. • Golobish, Thomas D. • Capponi, Vincent • Chan, Philip
Assignees
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Publication Number
US-8211310-B2
Publication Date
2012-07-03
Expiration Date
Abstract
A size-selective hemocompatible porous polymeric adsorbent system is provided, the polymer system comprises at least one polymer with a plurality of pores, and the polymer has at least one transport pore with a diameter from about 250 Angstroms to about 2000 Angstroms, and the polymer has a transport pore volume greater than about 1.8% to about 78% of a capacity pore of volume of the polymer.
Core Innovation
The invention defines a polymer system and/or size selective polymer with a porous structure in which the porous structure consists of pores having diameters in the range of 17 Angstroms to about 2000 Angstroms. The porous structure comprises transport pores with diameters from about 250 Angstroms to about 2000 Angstroms and effective pores with diameters greater than 100 Angstroms to about 250 Angstroms, with pore volume fractions defined relative to a capacity pore volume.
The problem addressed is the need for a hemocompatible porous polymeric adsorbent for extracorporeal blood/plasma perfusion/hemoperfusion that achieves size-selective uptake of blood proteins while preventing unwanted protein entry. The disclosed pore design supports selective protein adsorption based on molecular size, including sorption and exclusion of blood proteins in specified molecular-weight ranges.
An additional mechanism for selectivity is provided by a negative ionic charge on the polymer external surface that prevents albumin from entering the pores. This size-selective and hemocompatible porous polymeric system is described for extracorporeal perfusion and hemoperfusion, with pore characteristics used to influence selective protein uptake.
Claims Coverage
The relevant independent claims are directed to a polymer system and/or size selective polymer defined by specific pore diameter ranges and pore-volume fractions, and in some embodiments to albumin exclusion via a negatively charged external surface. Across the independent claims, the coverage is centered on quantitative porous structure definitions for transport pores and effective pores, plus the negative surface charge feature.
Quantitative porous structure with transport and effective pores
A polymer system consisting of polymers defining a porous structure wherein the porous structure consists of pores with diameters in the range of 17 Angstroms to about 2000 Angstroms, said porous structure comprising transport pores with diameters from about 250 Angstroms to about 2000 Angstroms and effective pores with diameters greater than 100 Angstroms to about 250 Angstroms, said polymer system having a transport pore volume greater than about 1.8 to about 78% of a capacity pore volume of said system and an effective pore volume greater than about 22 to less than about 98.2% of the capacity pore volume.
Size selective polymer with defined pore diameter ranges and pore-volume fractions
A size selective polymer defining a porous structure wherein the porous structure consists of pores with diameters in the range of 17 Angstroms to about 2000 Angstroms, said porous structure comprising transport pores with diameters from about 250 Angstroms to about 2000 Angstroms and effective pores with diameters greater than 100 Angstroms to about 250 Angstroms, said porous structure having a transport pore volume greater than about 1.8 to about 78% of a capacity pore volume of said porous structure and an effective pore volume greater than about 22 to less than about 98.2% of the capacity pore volume.
Albumin entry prevention via negative ionic charge on external surface
A size selective polymer system consisting of polymers defining a porous structure wherein the porous structure consists of pores with diameters in the range of 17 Angstroms to about 2000 Angstroms, said porous structure comprising transport pores with diameters from about 250 Angstroms to about 2000 Angstroms and effective pores with diameters greater than 100 Angstroms to about 250 Angstroms, said polymer system having a transport pore volume greater than about 1.8 to about 78% of a capacity pore volume of said system and an effective pore volume greater than about 22 to less than about 98.2% of the capacity pore volume, said polymer has an external surface with a negative ionic charge, said negative ionic charge prevents albumin from entering said pores.
Overall, the independent claims define a porous polymer system characterized by pore diameter ranges and specific transport/effective pore volume fractions relative to a capacity pore volume. Additional claim coverage includes preventing albumin entry through a negatively charged external surface.
Stated Advantages
Size-selective sorption of blood proteins based on molecular weight while excluding entry of albumin via preventing albumin from entering pores.
Hemocompatibility is stated for use as an extracorporeal blood/plasma perfusion/hemoperfusion adsorbent.
Documented Applications
Extracorporeal blood/plasma perfusion and hemoperfusion using a size-selective hemocompatible porous polymeric adsorbent.
Use described in relation to hemodialysis (in conjunction), and protein removal related to systemic inflammatory response syndrome (SIRS), sepsis/burns/trauma/influenza.
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