Resuscitation fluid
Inventors
Assignees
Publication Number
US-8198243-B2
Publication Date
2012-06-12
Expiration Date
2028-12-16
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Abstract
A method for treating conditions related to lack of blood supply with a lipid based resuscitation fluid is disclosed. The resuscitation fluid contains a lipid component and an aqueous carrier. The lipid component forms an emulsion with the aqueous carrier. The resuscitation fluid can be used to increase the blood pressure and to carry oxygen to tissues. The resuscitation fluid can also be used for preserving the biological integrity of donor organs for transplantation.
Core Innovation
The invention relates to a method and composition for treating conditions associated with a lack of blood supply by administering a lipid based resuscitation fluid. This resuscitation fluid consists of a lipid component and an aqueous carrier, where the lipid component forms an emulsion with the carrier, enabling the fluid to function both as a volume expander and an oxygen carrier. The emulsion is characterized by lipid micelles with a polar outer surface and an inner hydrophobic space, which allows it to carry and deliver oxygen to tissues.
The problem addressed by this invention is the need for a lower-cost resuscitation fluid capable of expanding blood volume and carrying substantial amounts of oxygen while avoiding the complexities and drawbacks associated with current blood substitutes. Existing substitutes, such as perfluorocarbons, require complex and costly purification processes due to their toxicity and need for high purity, while hemoglobin-based substitutes can cause renal toxicity and are expensive with a short shelf-life.
This lipid based resuscitation fluid also offers methods for preserving the biological integrity of donor organs by perfusing them with the oxygen-carrying emulsion. The invention further discloses resuscitation kits containing the fluid and devices for oxygenating the fluid prior to administration, providing versatile options for both emergency and organ preservation situations.
Claims Coverage
There is one independent claim defining the primary inventive feature of the patent.
Raising blood pressure using a lipid based resuscitation fluid containing an emulsion of lipid micelles
The main inventive feature is a method for raising blood pressure in a human or animal subject suffering from hypovolemia or ischemia by administering an effective amount of a lipid based resuscitation fluid. The fluid must include a lipid component and an aqueous carrier, with the lipid component forming an emulsion with the carrier specifically in the form of lipid micelles that have a polar outer surface and an inner hydrophobic space.
The claims primarily cover the use of a lipid based resuscitation fluid, structured as an emulsion of lipid micelles, for the purpose of raising blood pressure in conditions of reduced blood volume or blood supply.
Stated Advantages
Provides a lower-cost alternative to current blood substitutes by functioning as both a volume expander and an oxygen carrier.
Avoids the toxicity and complex purification issues associated with perfluorocarbon-based and hemoglobin-based blood substitutes.
Has the ability to increase blood pressure and carry oxygen to tissues.
May be used to preserve the biological integrity of donor organs for transplantation.
Can more effectively restore and maintain blood pressure following severe hemorrhage than standard resuscitation fluids.
Documented Applications
Treatment of conditions related to lack of blood supply, including hypovolemia, ischemia, hemodilution, trauma, septic shock, cancer, anemia, cardioplegia, hypoxia, and organ perfusion.
Use as a resuscitation fluid administered intravenously or intraarterially to raise blood pressure and carry oxygen.
Preservation of the biological integrity of mammalian donor organs by perfusing them with the lipid based resuscitation fluid during organ transplantation.
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