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Abstract
A sensor for sensing a target chemical with high signal-to-noise ratio is disclosed. In some embodiments, the sensor comprises a sensing region that is optically coupled with an attenuation region. The sensing region receives optical stimulation that comprises light characterized by an excitation wavelength. In response to exposure to the target chemical, the sensing region fluoresces at a fluorescence wavelength. The attenuation region receives light from the fluorescing sensing region that includes light characterized by the fluorescence wavelength (i.e., signal) and light characterized by the excitation wavelength (i.e., noise). The attenuation region conveys the light to a detector that provides an electrical output signal based on the target chemical. While conveying the light, however, the attenuation region improves the signal-to-noise ratio by attenuating light characterized by the excitation wavelength more than light characterized by the fluorescence region.
Core Innovation
The invention provides a fluorescence chemical sensor implemented with optical waveguides on a planar lightwave circuit (PLC). The sensor includes a sensing region and an in-line attenuation region in which excitation-wavelength light is attenuated more than fluorescence-wavelength light, improving signal-to-noise ratio (SNR) while both types of light propagate in the PLC. The sensing region produces a fluorescence signal characterized by a fluorescence wavelength when exposed to a target chemical and excitation light characterized by an excitation wavelength.
The attenuation region improves selectivity by coupling excitation-wavelength light using resonant element structures. The attenuation region includes a resonant element having a resonance at the excitation wavelength, where the resonant element couples light characterized by the excitation wavelength from one waveguide portion into another waveguide portion to remove or redirect the excitation light away from detection. This excitation-selective coupling is used to attenuate excitation light more than the fluorescence signal.
Different attenuation implementations are described, including wavelength-selective absorbing dye with cladding thinning to increase interaction length, shaped waveguide sections including spiral waveguide sections to extend dye interaction length, and resonant elements such as a racetrack ring resonator tuned to the excitation wavelength. The disclosure also describes embodiments including multi-sensor configurations, two-dimensional sensor arrays, and monolithic integration where a plurality of sensing regions are arranged in a two-dimensional arrangement and each sensing region is optically coupled to a corresponding attenuation region.
Claims Coverage
The document provides three independent claim sets for sensor structures and a sensing method that share a common inventive concept: an attenuation region that selectively couples excitation-wavelength light based on resonant element resonance, while allowing fluorescence-wavelength light to proceed to detection. Across the independent claims, the main inventive features cover selective attenuation by resonant coupling, waveguide portion partitioning in sensing and attenuation regions, and two-dimensional multi-region sensor arrangements.
Fluorescence sensing region and excitation-selective resonant attenuation
a first sensing region that comprises a first material and a first waveguide portion, wherein the first material and the first waveguide portion are optically coupled, and wherein the first material provides a first fluorescence signal that is characterized by a first fluorescence wavelength when exposed to a first target chemical and light that is characterized by a first excitation wavelength; a first attenuation region, wherein the first attenuation region comprises a second waveguide portion that receives light from the first sensing region, a first resonant element that has a resonance at the first excitation wavelength, and a third waveguide portion, wherein the first resonant element couples light characterized by the first excitation wavelength from the second waveguide portion to the third waveguide portion.
Excitation-selective attenuation region for fluorescence-based sensing
attenuating the first light signal in the attenuation region, wherein the attenuation region attenuates light characterized by the excitation wavelength more than it attenuates the fluorescence signal, and wherein the attenuation region attenuates the first light signal by selectively coupling light characterized by the excitation wavelength from the second waveguide portion into a third waveguide portion.
Two-dimensional sensing regions with excitation-resonant attenuation regions on a substrate
a substrate comprising a plurality of sensing regions and a plurality of attenuation regions, each of the plurality of sensing regions being optically coupled with a different one of the plurality of attenuation regions, wherein the plurality of sensing regions are arranged in a two-dimensional arrangement; the plurality of attenuation regions, each attenuation region comprising a first waveguide portion; a second waveguide portion; and a resonant element that is dimensioned and arranged to be resonant at the excitation wavelength, wherein the resonant element couples light characterized by the excitation wavelength from the first waveguide portion to the second waveguide portion.
Across the independent claims, the inventive concept is implemented by optical waveguide-coupled sensing regions that generate fluorescence signals upon exposure to a target chemical and excitation light, and attenuation regions that selectively attenuate excitation-wavelength light more than fluorescence-wavelength light via excitation-resonant coupling into additional waveguide portions. The multi-region independent claim further extends this architecture to a substrate with multiple sensing and attenuation regions arranged in a two-dimensional arrangement.
Stated Advantages
Improves signal-to-noise ratio (SNR) by attenuating excitation-wavelength light more than fluorescence-wavelength light.
Documented Applications
Multi-sensor and two-dimensional mapping embodiments using a plurality of sensing regions arranged in a two-dimensional arrangement, with each sensing region optically coupled to a corresponding attenuation region.
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