Kinetic determination of peracid and/or peroxide concentrations
Inventors
Assignees
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Publication Number
US-8119412-B2
Publication Date
2012-02-21
Expiration Date
Abstract
A use composition monitor determines the concentration of peracid and/or peroxide in a use composition using a kinetic assay procedure. A sample mixture containing a sample of the use composition, a diluent and at least one reagent is prepared and analyzed using, for example, an optical detector. Response data obtained by the detector is indicative of the optical absorbance of the sample mixture as a function of time. A processor analyzes the response data to determine a corresponding best fit linear relationship. The initial absorbance of the sample mixture is indicative of the concentration of peracid in the use composition, while the slope of the best fit equation is indicative of the concentration of peroxide in the use composition.
Core Innovation
The disclosed invention relates to a kinetic, optical monitoring approach for determining concentrations of peracid and peroxide in a use composition. A sample mixture is prepared that includes a reagent comprising an iodide compound and a sample of a use composition having a concentration of peracid and a concentration of peroxide to be determined. Response data indicative of absorbance of the sample mixture are collected as a function of time, and the concentrations are determined based on that response data.
The core determination uses a best fit linear relationship between absorbance-indicative response data and time, where the best fit linear relationship includes a slope and a y-intercept. The peracid concentration is calculated based on the y-intercept, and the peroxide concentration is calculated based on the slope. This approach is implemented in both a method and a system, with a sequential injection manifold configured to prepare the sample mixture and a detector to obtain the time-dependent absorbance response.
The disclosed system includes processing configured to perform the linear relationship determination and concentration calculations, and it is configured to obtain absorbance indicative response data from the sample mixture as a function of time. The disclosed content further addresses reaction-rate rationale using the relative competitive oxidation of iodide to triiodide by peracid versus peroxide, includes reagent blank/reference handling, and uses regression with correction for detector time lag. Optional configurations include temperature-regulated optical sensor operation and multiwavelength detection within a defined wavelength range.
The monitoring is described in the context of antimicrobial use compositions and is further used for reaction-rate rationale and operational control actions. The disclosed content includes feedback control concepts and threshold-based replenishment and disposal of use composition based on peracid and peroxide concentrations, including adding a peracid concentrate when below a minimum peracid threshold concentration and emptying/discarding spent use composition when peroxide is above a maximum threshold.
Claims Coverage
The partial document provides two independent claims (a method and a system). Both claims rely on kinetic absorbance-versus-time data fitted to a best fit linear relationship (slope and y-intercept) to calculate peracid and peroxide concentrations, using an iodide-containing reagent in a prepared sample mixture.
Iodide reagent sample mixture for peracid and peroxide determination
A sample mixture is prepared that includes a reagent comprising an iodide compound and a sample of a use composition having a concentration of peracid and a concentration of peroxide to be determined.
Kinetic absorbance response versus time acquisition
Response data indicative of absorbance of the sample mixture are collected as a function of time (or obtained by a detector as response data indicative of absorbance as a function of time).
Best fit linear relationship using slope and y-intercept
The concentration of the peracid and the concentration of the peroxide are determined by determining a best fit linear relationship between the data indicative of the absorbance of the sample mixture and time, the best fit linear relationship including a slope and a y-intercept, and then calculating the peracid concentration based on the y-intercept and calculating the peroxide concentration based on the slope.
Sequential injection manifold system architecture
A sequential injection manifold is configured to prepare the sample mixture that includes the iodide-compound reagent and the sample of the use composition with peracid and peroxide concentrations to be determined.
Detector and processor configured for absorbance-based concentration calculations
A detector is configured to obtain response data indicative of absorbance as a function of time from the sample mixture, and a processor is configured to determine the concentration of peracid and peroxide in the use composition based on the response data using a best fit linear relationship with slope and y-intercept to calculate the peracid and peroxide concentrations.
Across the independent claims, the inventive coverage centers on preparing an iodide-containing sample mixture from a use composition, collecting detector response indicative of absorbance as a function of time, and determining peracid and peroxide concentrations by fitting absorbance-versus-time data to a best fit linear relationship that includes a slope and a y-intercept.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Monitoring peracid and hydrogen peroxide (peroxide) in antimicrobial use compositions.
Feedback control and threshold-based replenishment/disposal of use composition based on peracid and peroxide concentrations, including adding a peracid concentrate when below a minimum peracid threshold concentration and emptying/discarding spent use composition when peroxide is above a maximum threshold.
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