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Publication Number
US-8063264-B2
Publication Date
2011-11-22
Expiration Date
Abstract
A wound dressing and a method for enhancing the clotting comprising a plurality of hydrophilic microfibers bonded to each other to form a mat with the plurality of microfibers having a pore size sufficiently small to inhibit wicking platelets from a wound into the microfibers so that when applied to a wound the blood coagulates and the microfibers remain external to the wound.
Core Innovation
The invention relates to a wound dressing/homeostasis media that enhances clotting at a wound by using a plurality of hydrophilic microfibers forming a mat having open pores located between adjacent microfibers. The open pores have a pore size sufficiently small to inhibit wicking of a platelet away from a wound and into the mat while allowing ingress of plasma into the mat.
The disclosed structure is made from hydrophilic microfibers and the mat includes open pores between fibers. By allowing plasma to enter while inhibiting platelets from migrating into the mat, the media accelerates clotting at a wound site. The disclosure further focuses on enabling the mat to conform to the contour or shape of the wound site while being held on the wound site sufficiently long for plasma wicking into the hydrophilic fibers.
In addition, the disclosed wound dressing includes biocompatible and bioabsorbable polymer fibers, including polyglycolic acid and polylactic acid. The microfibers can include surface irregularities and non-circular cross-sections with lobes, and the mat can include embedded hemostatic particles and/or hemostatic agents, with bonding techniques used to form and hold the microfibers together in a non-shedding porous mat.
Claims Coverage
The independent claims cover four core constructs: a wound dressing formed from a hydrophilic microfiber mat with open pores that inhibit platelet wicking while allowing plasma ingress; a method of accelerating clotting by holding such a mat to enable plasma wicking, inhibiting platelet migration, and conforming to the wound contour; a homeostasis media with a hydrophilic fiber mat having open pores dimensioned to inhibit platelet passage while allowing plasma ingress; and a wound dressing comprising a hemostatic fibrous media in which a hydrophilic microfiber surface arranged to form open pores enables plasma ingress while inhibiting platelet wicking away and promotes wicking of water through the hydrophilic microfiber.
Hydrophilic microfiber mat with open pores inhibiting platelet wicking and allowing plasma ingress
A wound dressing comprising a plurality of hydrophilic microfibers forming a mat with open pores between adjacent microfibers, where each open pore has a pore size sufficiently small to inhibit wicking of a platelet away from a wound and into the mat while allowing ingress of plasma into said mat.
Holding a hydrophilic fiber mat to allow plasma wicking while inhibiting platelet migration and conforming to wound contour
A method of accelerating the clotting of blood at a wound site by holding a mat of hydrophilic fibers on the wound site sufficiently long to allow plasma in the blood to wick into the hydrophilic fibers while inhibiting platelets from migrating into the mat and conforming the mat to the contour or shape of the wound site.
Homeostasis media of hydrophilic fiber mat with open pores sized to inhibit platelet passage while allowing plasma ingress
A homeostasis media comprising a plurality of hydrophilic fibers forming a mat with open pores therebetween, where the open pores have a dimension sufficiently small to inhibit blood platelets therethrough while allowing ingress of plasma into said mat to promote wicking of the blood platelets at a wound.
Hemostatic fibrous media with hydrophilic microfiber arranged to form open pores for plasma ingress and inhibited platelet wicking
A wound dressing for enhancing blood clotting comprising a hemostatic fibrous media wherein a surface of a hydrophilic microfiber is arranged to form a set of open pores in the fibrous media with the set of open pores having a pore size sufficiently small to inhibit wicking platelets away from a wound and into the media via the set of pores while allowing ingress of plasma through the set of pores while the hydrophilic microfiber enhances wicking of water therethrough.
Across the independent claims, the shared inventive theme is a hydrophilic, porous fibrous mat or media with open pores sized to inhibit platelet wicking, platelet migration, or platelet passage while allowing plasma ingress to promote clotting-related wicking, with additional emphasis on holding the mat to enable plasma wicking and conforming it to wound contour.
Stated Advantages
Accelerating the clotting of blood at a wound site.
Enhancing the clotting at a wound.
Inhibiting wicking of platelets away from a wound and into the mat/media.
Allowing ingress of plasma into the mat to promote wicking related to clotting.
Minimizing the chances of contaminating the wound by holding the mat on the wound site while plasma wicks into the hydrophilic fibers.
Conforming the mat to the contour or shape of the wound site.
Enhancing wicking of water therethrough.
Documented Applications
Wound dressing use for enhancing clotting at a wound site by employing hydrophilic microfiber/hemostatic fibrous media with open pores.
Homeostasis media use to promote wicking of blood platelets at a wound by using a hydrophilic fiber mat with open pores sized to inhibit platelet passage while allowing plasma ingress.
Method use for accelerating blood clotting at a wound site by holding a mat of hydrophilic fibers on the wound site sufficiently long to allow plasma wicking while inhibiting platelet migration and conforming the mat to the wound contour or shape.
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