Use of S-adenosylmethionine, vitamin E, and vitamin C for the treatment of oxidative liver injury and insulin resistance
Inventors
Lautt, Wilfred Wayne • Ming, Zhi
Assignees
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Publication Number
US-8063024-B2
Publication Date
2011-11-22
Expiration Date
Abstract
The present invention provides antioxidant compositions comprising S-adenosylmethionine (SAMe), vitamin E and vitamin C and uses thereof for the treatment of liver injury and insulin resistance.
Core Innovation
The invention relates to antioxidant compositions and methods for treating insulin resistance by administering S-adenosylmethionine (SAMe) or a derivative or pharmaceutically acceptable salt, vitamin E or a derivative or pharmaceutically acceptable salt, and vitamin C or a derivative or pharmaceutically acceptable salt to a patient in need thereof. The described approach targets oxidative liver injury and the resulting insulin resistance, emphasizing combination therapy for protection.
The disclosed background framework identifies HISS-dependent insulin resistance (HDIR) following liver injury, including the hepatic insulin sensitizing substance (HISS) and HISS action blockade. The document describes using the Rapid Insulin Sensitivity Test (RIST) index to assess liver function and insulin sensitivity, including changes to the HISS-dependent component after liver injury.
In a rat acute liver injury model using thioacetamide (TAA), the disclosed combination of SAMe with vitamin C and vitamin E partially restores the RIST index and improves the HISS-dependent component compared with SAMe alone or vitamins alone. The combination is also reported to reduce ALT/AST increases and markedly improve liver histopathology, including inflammation, necrosis, and bridging necrosis, relative to less comprehensive treatments.
Claims Coverage
The provided claim set includes one independent claim reciting a method of treating insulin resistance using a three-antioxidant regimen, with one dependent claim narrowing the insulin resistance subtype to HISS-dependent insulin resistance.
Treating insulin resistance with SAMe, vitamin E, and vitamin C
A method of treating insulin resistance by administering a therapeutically effective amount of S-adenosylmethionine or a derivative or pharmaceutically acceptable salt, vitamin E or a derivative or pharmaceutically acceptable salt, and vitamin C or a derivative or pharmaceutically acceptable salt to a patient in need thereof.
Treating HISS-dependent insulin resistance
The method of treating insulin resistance is characterized by insulin resistance that is HISS-dependent insulin resistance.
Across the claims provided, the core claim feature is the administration of SAMe together with vitamin E and vitamin C to treat insulin resistance, and the dependent claim specifies that the targeted insulin resistance is HISS-dependent.
Stated Advantages
Combination therapy yields synergistic protection against oxidative liver injury and the resulting insulin resistance.
Partially restores the RIST index, improving the HISS-dependent component compared with SAMe alone or vitamins alone.
Reduces ALT/AST increases.
Markedly improves liver histopathology, including inflammation, necrosis, and bridging necrosis.
Documented Applications
Treatment of insulin resistance in a patient, including insulin resistance associated with oxidative liver injury and HISS-dependent insulin resistance.
Assessment of liver function and insulin sensitivity using the Rapid Insulin Sensitivity Test (RIST) index, including the HISS-dependent component, after liver injury.
Use in a rat acute liver injury model using thioacetamide (TAA) to evaluate the effects on RIST index, ALT/AST, and liver histopathology.
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