Resuscitation fluid
Inventors
Assignees
Publication Number
US-8063020-B2
Publication Date
2011-11-22
Expiration Date
2028-12-16
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Abstract
A method for treating conditions related to lack of blood supply with a lipid based resuscitation fluid is disclosed. The resuscitation fluid contains a lipid component and an aqueous carrier. The lipid component forms an emulsion with the aqueous carrier. The resuscitation fluid can be used to increase the blood pressure and to carry oxygen to tissues. The resuscitation fluid can also be used for preserving the biological integrity of donor organs for transplantation.
Core Innovation
The invention relates to a method and composition for treating conditions associated with a lack of blood supply by using a lipid based resuscitation fluid. This fluid contains a lipid component that forms an emulsion with an aqueous carrier, resulting in lipid micelles with a polar outer surface and an inner hydrophobic space. The fluid is designed to increase blood pressure and carry oxygen to tissues, and it can also preserve the biological integrity of donor organs for transplantation.
The problem being addressed is the need for a lower-cost resuscitation fluid that both expands blood volume and is capable of carrying a large amount of oxygen. Existing blood substitutes rely on perfluorocarbons (PFCs) or hemoglobins, which are expensive to produce, have significant toxicity issues, require complex purification or modification, and have limited shelf-lives. The disclosed invention aims to overcome these limitations by providing a resuscitation fluid using emulsified lipids as the functional oxygen carrier.
The resuscitation fluid may further include various additives, such as buffering agents, plasma components, oncotic or crystalloid agents, and other pharmaceutically acceptable substances to tailor osmotic, ionic, and physiologic properties. The invention also discloses methods for oxygenating the fluid prior to use, preparation methods for mixing and emulsifying components, and kits containing both the fluid and supporting devices such as oxygenation apparatus or infusion equipment. Use cases include both immediate medical treatment for hemorrhagic shock and organ preservation for transplantation.
Claims Coverage
There are three independent claims in this patent, each defining a method for treating hemorrhagic shock in a subject using a lipid based resuscitation fluid with specified composition and administration steps.
Method for treating hemorrhagic shock using a lipid based resuscitation fluid forming lipid micelles
The inventive feature is a method comprising: - Administering an effective amount of a lipid based resuscitation fluid to a human or animal subject suffering hemorrhagic shock. - The fluid comprises a lipid component and an aqueous carrier. - The lipid component forms an emulsion with the aqueous carrier in the form of lipid micelles with a polar outer surface and an inner hydrophobic space.
Method for treating hemorrhagic shock using a lipid based resuscitation fluid with specified additives
The inventive feature is a method comprising: - Administering an effective amount of a lipid based resuscitation fluid to a human or animal subject with hemorrhagic shock. - The fluid consists essentially of: - a lipid component, - a polar liquid carrier, - and at least one additive selected from the group consisting of oncotic agents, crystalloid agents, buffering agents, carbohydrates, salts, vitamins, amino acids, vessel expanders, antibodies, and surfactants. - The lipid component forms an emulsion with the polar liquid carrier in the form of lipid micelles with a polar outer surface and an inner hydrophobic space.
Method for treating hemorrhagic shock using a lipid based resuscitation fluid administered without further encapsulation
The inventive feature is a method comprising: - Administering to a human or animal subject an effective amount of a lipid based resuscitation fluid. - The fluid comprises a lipid component and an aqueous carrier. - The lipid component forms an emulsion with the aqueous carrier in the form of lipid micelles with a polar outer surface and an inner hydrophobic space. - The emulsion is administered into the subject without further encapsulation.
The inventive features focus on methods of using a lipid based resuscitation fluid that forms an emulsion of lipid micelles for the treatment of hemorrhagic shock, with flexibility in composition and administration, and with or without specific additives or encapsulation.
Stated Advantages
The resuscitation fluid offers a lower cost alternative to perfluorocarbon- and hemoglobin-based substitutes while functioning as both a volume expander and an oxygen carrier.
The formulation avoids the toxicity and complex purification problems associated with perfluorocarbons and the renal toxicity and short shelf-life of hemoglobin-based substitutes.
The resuscitation fluid can rapidly increase blood pressure and effectively carry oxygen to tissues during severe hemorrhagic shock.
The solution can preserve the biological integrity of donor organs for transplantation procedures.
The resuscitation fluid allows for tailored ionic and osmotic properties, which can help control conditions like edema and cardiac arrhythmias during treatment.
Documented Applications
Treatment of conditions related to lack of blood supply, including hypovolemia, ischemia, hemodilution, trauma, septic shock, cancer, anemia, cardioplegia, hypoxia, and organ perfusion.
Rapid restoration of blood pressure and oxygen delivery in cases of severe hemorrhagic shock.
Preservation of biological integrity of organs from mammalian donors for use in transplantation.
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