Device for needleless injection operating with two concentric energetic materials
Inventors
Alexandre, Patrick • Brouquieres, Bernard • Gautier, Philippe • Reynaud, Christiane
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Assignees
Member
CrossjectCrossject is a specialty pharmaceutical company focused on drug-device combination products for emergency medicine. Leveraging a proprietary needle-free auto-injection platform, the company develops and manufactures fast-acting treatments for life-threatening situations such as epilepsy, adrenal crisis, and anaphylaxis. Crossject conducts advanced regulatory development, clinical validation, and large-scale industrialization to deliver innovative therapies for global markets, with an emphasis on simplicity, reliability, and patient usability.
Crossject is a specialty pharmaceutical company focused on drug-device combination products for emergency medicine. Leveraging a proprietary needle-free auto-injection platform, the company develops and manufactures fast-acting treatments for life-threatening situations such as epilepsy, adrenal crisis, and anaphylaxis. Crossject conducts advanced regulatory development, clinical validation, and large-scale industrialization to deliver innovative therapies for global markets, with an emphasis on simplicity, reliability, and patient usability.
Publication Number
US-7981075-B2
Publication Date
2011-07-19
Expiration Date
Abstract
A needleless injection device used for intradermal, subcutaneous and intramuscular injections is disclosed. The device includes a pyrotechnic gas generator, at least one piston, a reserve of liquid active principle and an injection nozzle. The generator includes a pyrotechnic charge composed of a central energetic material that is surrounded by a second peripheral energetic material. The entire outer surface of the central energetic material contacts the inner surface of the peripheral energetic material. The two energetic materials have different rates of combustion.
Core Innovation
The invention relates to a needleless injection device comprising a pyrotechnic gas generator having a pyrotechnic charge made of two energetic materials with different rates of combustion. One energetic material is central and is surrounded by the other energetic material which is peripheral, and the whole of the outer surface of the central energetic material is in contact with the inner surface of the peripheral energetic material.
The device further includes at least one piston, a reserve of liquid active principle, and an injection nozzle. Combustion of the central and peripheral energetic materials creates pressure-profile phases at the nozzle, intended to control skin penetration and injection depth during intradermal, subcutaneous, or intramuscular injection.
Preferred embodiments describe how the central and peripheral energetic materials are formed so that the combustion rates differ, including powder grains with central and peripheral layers, a single powder with a peripheral rate of combustion different from the central rate, encapsulated liquid or gel central material with a solid peripheral energetic material, and monolithic block architectures with a central channel. The peripheral energetic material may be implemented as nitrofilm, with a specified nitrofilm composition.
Claims Coverage
The partial document identifies two independent claims (clm-00001 and clm-00020). Across both independent claims, the coverage centers on the same core arrangement: a pyrotechnic gas generator with a central and peripheral energetic-material configuration in full interfacial contact, having different combustion rates, coupled to a piston-driven delivery of a liquid active principle through an injection nozzle.
Central and peripheral energetic materials with full interfacial contact and different combustion rates
A pyrotechnic gas generator including a pyrotechnic charge composed of two energetic materials having different rates of combustion, wherein one energetic material is central and is surrounded by the other energetic material which is peripheral, and the whole of the outer surface of the central energetic material is in contact with the inner surface of the peripheral energetic material.
Piston-driven liquid active principle delivery to an injection nozzle based on combustion
A reserve of liquid active principle and an injection nozzle, wherein at least one piston moves the liquid active principle through the reserve and into the injection nozzle based on combustion of the central and peripheral energetic materials.
The independent claims collectively require a pyrotechnic gas generator with a central energetic material surrounded by a peripheral energetic material, fully contacting at their outer/inner surfaces, and having different rates of combustion. This combustion is used to drive at least one piston that moves a liquid active principle from a reserve chamber through an injection nozzle.
Stated Advantages
Reproducible pressure profiles.
Reliability/safety.
Compact disposable device without geometry changes.
Documented Applications
Intradermal injections, subcutaneous injections, and intramuscular injections of a liquid active principle using the needleless injection device.
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