Device for the modulation of cardiac end diastolic volume
Inventors
Criscione, John C. • Biswas, Saurabh • Hall, Stan • Harrison, Lewis • Robbins, Dennis
Assignees
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Publication Number
US-7871366-B2
Publication Date
2011-01-18
Expiration Date
Abstract
The present invention provides methods, systems, kits and devices that reduce dyskinesis and hypokinesis. For example, the direct compression cardiac device may be positioned about at least a portion of a heart, and includes a resilient inner panel in contact with at least a portion of the heart periphery, one or more resilient members positioned about the resilient inner panel and at least partially surrounded by an expandable outer panel. The resistance supplied by the inner panel to the heart may be modulated to control the end-diastolic heart volume and remodel the heart, the resistance supplied by the expandable outer panel to the heart may be modulated to control the end-systolic heart volume and remodel the heart or both.
Core Innovation
The direct cardiac compression heart assist device comprises a resilient inner panel in contact with at least part of the heart periphery and an expandable or inflatable outer panel positioned at least partially around it. The panels provide resistance to heart movement to control end-diastolic heart volume, end-systolic heart volume, or both. The contoured device compresses the heart during contraction without inverting or significantly perturbing its natural curvatures.
The device addresses cardiac volume modulation and shape remodeling to support myocardial recovery while preserving natural cardiac curvatures. Resistance supplied by the panels modulates heart volume, with pressurization configured to compress the heart and reduce dyskinesis and hypokinesis. The system facilitates minimally invasive delivery around the heart periphery, operation without suturing, and gradual withdrawal during recovery.
Claims Coverage
The four independent claims are claims 1, 11, 14, and 26, identifying four inventive features directed to volume modulation, shape remodeling, a compression heart assist device, and device implantation.
Individual modulation of heart volume
Claim 1 covers a method using a direct compression cardiac device with a resilient inner panel and an expandable outer panel, wherein resistance supplied by the inner panel, the outer panel, or both is modulated to control end-diastolic heart volume, end-systolic heart volume, or both, while compressing the heart without inverting or significantly perturbing its curvatures.
Remodeling the shape of a heart
Claim 11 covers a method of remodeling heart shape by determining heart shape and modulating resistance supplied by a resilient inner panel, resilient members, and an expandable outer panel to control end-diastolic and end-systolic heart volume while preserving curvatures during compression.
Direct cardiac compression heart assist device
Claim 14 covers a device comprising a resilient inner panel contoured to supply resistance affecting end-diastolic heart volume and an inflatable outer panel supplying resistance affecting end-systolic heart volume, configured with fluid connections for pressurization and depressurization to compress the heart without inverting or significantly perturbing curvatures.
Implantation of a direct cardiac compression heart assist device
Claim 26 covers a method of implanting and positioning a contoured device around the heart periphery, comprising a resilient inner panel affecting end-diastolic heart volume and an inflatable outer panel affecting end-systolic heart volume, including pressurization to compress the heart during contraction without inverting or significantly perturbing its curvatures. [procedural detail omitted for safety]
The independent claims collectively protect methods for heart volume control and shape remodeling through panel resistance, the dual-panel direct cardiac compression apparatus, and implantation methods characterized by curvature-preserving compression.
Stated Advantages
The device compresses the heart during contraction without inverting or significantly perturbing the curvatures of the heart.
Resistance from the inner and outer panels can be modulated to control end-diastolic heart volume, end-systolic heart volume, or both to remodel the shape of the heart.
The device reduces dyskinesis and hypokinesis while supporting myocardial recovery and heart shape remodeling.
The device is configured for minimally invasive delivery, potential use without suturing to the heart, and gradual withdrawal as the heart recovers.
The disclosure reports elimination of infarct-related dyskinesis in testing.
Documented Applications
A direct cardiac compression heart assist device for providing support and mechanical assistance around the heart.
Individual modulation of heart volume by controlling end-diastolic heart volume, end-systolic heart volume, or both.
Remodeling the shape of a heart by controlling end-diastolic and end-systolic heart volume.
Implantation and positioning of a direct cardiac compression heart assist device about the heart periphery.
Incorporation of sensors or electrodes for cardiac pacing, defibrillation, or electrical stimulation.
Implanting, coating, or disseminating bioactive agents in association with the device.
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