System and method for transplantation of dermal tissue
Inventors
Eriksson, Elof • Johnson, Royce • Mishra, Ajit • Girouard, Michael • Ohira, Makoto
Assignees
Applied Tissue Technologies LLC • Solventum Intellectual Properties Co
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Publication Number
US-7666134-B2
Publication Date
2010-02-23
Expiration Date
Abstract
A dermal tissue transplantation system combining a tissue particle harvester, a tissue particle collector, and a chambered dressing. The system provides a harvester capable of harvesting tissue from a donor site on the order of about 100 microns. The integrated tissue particle collector provides a means for collecting the harvested tissue for in situ cultivation in a chambered dressing at the wound site.
Core Innovation
The invention is a dermal tissue nanografting system that includes a dermal tissue particle harvester assembly, a dermal tissue particle collector, a nanograft cell, and a particle retriever. The particle harvester assembly has a housing with a port, a rotatable shaft, and a dermal tissue cutting tool mounted on the rotatable shaft, where the cutting tool is received within an opening in the housing.
The invention is directed to harvesting dermal tissue into dermal tissue particles and using those particles in a chambered dressing configured for in situ cultivation. The system includes components for collecting harvested dermal tissue particles for seeding into the nanograft cell while maintaining viability prior to seeding.
A particle retriever is configured to be received by the port and inject dermal tissue into the nanograft cell, so that graft tissue propagates at the wound site. The disclosed implementations also describe multiple cutting tool configurations for producing dermal tissue particles using a motor-driven cutting tool housed with an orifice, and different collector retrieval approaches including syringe- or port-based injection and flushing approaches with luer ports.
Claims Coverage
The independent claim recites four interacting system elements: a motor-driven dermal tissue particle harvester assembly with a housing port and a rotatable cutting tool, a dermal tissue particle collector, a nanograft cell, and a particle retriever configured to be received by the port to inject dermal tissue into the nanograft cell. Dependent claims refine the cutting tool form and define specific structural or parameter constraints.
Motor-driven dermal tissue particle harvester assembly with housing port and rotating cutting tool
A housing with a port; a rotatable shaft; a dermal tissue cutting tool mounted on the rotatable shaft, received within an opening in the housing; and an electric motor coupled to the rotatable shaft, wherein the dermal tissue cutting tool is configured to rotate within the opening when the electric motor is operated.
Particle retriever injects dermal tissue into the nanograft cell
A particle retriever configured to be received by the port and to inject dermal tissue into the nanograft cell.
Nanograft cell and dermal tissue particle collector
A dermal tissue particle collector and a nanograft cell included with the system.
Cutting tool penetration depth range
The cutting tool is configured to extend into the dermal tissue surface from approximately 0.01 mm to approximately 0.9 mm.
Luer fitting port
The system includes a port that is a Luer fitting.
Syringe particle retriever
The particle retriever is a syringe.
Rotary drum cutting tool
The cutting tool is configured as a rotary drum.
Tapered cylinder cutting tool
The cutting tool is configured as a tapered cylinder.
Across the claim set, coverage centers on combining a motor-driven rotatable dermal tissue cutting tool housed with a port, together with a collector and a nanograft cell. The particle retriever is configured to receive at the port and inject dermal tissue into the nanograft cell, with dependent refinements specifying penetration depth range and particular port, retriever, and cutting tool configurations.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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