Method for preparing particles of radioactive powder containing Cesium-131 for use in brachytherapy sources
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Publication Number
US-7316644-B2
Publication Date
2008-01-08
Expiration Date
Abstract
The present invention provides a method of preparing Cesium-131 (Cs-131) as a dispersed radioisotope. Uses of the dispersed Cs-131 prepared by the method include cancer research and treatment, such as for the use in brachytherapy. Cs-131 is particularly useful in the treatment of faster growing tumors.
Core Innovation
The invention prepares particles of radioactive powder containing Cs-131 by contacting Cs-131 with a material comprising a crystalline silicotitanate and an aluminosilicate to produce Cs-131-containing microparticles. The resulting microparticles retain Cs-131 within their particle structure to form very small particle sizes suitable for dispersion.
The invention addresses Cs-131 retention versus Cs-131 leaching by using the crystalline silicotitanate with an aluminosilicate, and optionally by exposing the radioactive particles to a bonding agent and, in a narrowed example, using heat. The partial content describes retention/leaching behavior and compares material behavior when Na silicate/aluminum oxide ceramic is present versus when crystalline silicotitanate is present.
The invention further uses the prepared Cs-131 microparticles to form brachytherapy devices by dispersing the radioactive microparticles in organic, polymeric, or inorganic matrices. The documented use includes subjecting a radiation-susceptible tumor to the brachytherapy device for radiation therapy from Cs-131.
Claims Coverage
The independent claim set includes two independent claims with inventive features related to preparing Cs-131-containing radioactive microparticles using a crystalline silicotitanate and an aluminosilicate, and using microparticle-containing brachytherapy devices for treating radiation-susceptible tumors using Cs-131 radiation.
Contacting Cs-131 with crystalline silicotitanate and aluminosilicate to form microparticles
A method for preparing particles of radioactive powder containing Cs-131 by contacting Cs-131 with a material to produce microparticles of radioactive powder containing Cs-131, wherein the material comprises a crystalline silicotitanate and an aluminosilicate.
Brachytherapy device with Cs-131 microparticles comprising crystalline silicotitanate and aluminosilicate
A brachytherapy device comprising microparticles of radioactive powder containing Cs-131, wherein the microparticles comprise Cs-131 and a crystalline silicotitanate and an aluminosilicate.
Overall, the claim coverage centers on Cs-131-containing microparticles made using crystalline silicotitanate together with an aluminosilicate, and on brachytherapy devices that incorporate those microparticles, with further claim dependency linking the device to treating a radiation-susceptible tumor with Cs-131 radiation.
Stated Advantages
Improved Cs-131 retention relative to Cs-131 leaching is described in connection with the presence of crystalline silicotitanate versus Na silicate/aluminum oxide ceramic.
Documented Applications
Preparing Cs-131-containing radioactive microparticles for use in brachytherapy devices.
Treating a radiation-susceptible tumor by subjecting the tumor to the brachytherapy device for Cs-131 radiation therapy.
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