Drug delivery system
Inventors
Bussiere, John Richard • Latouche, Eduardo Luis • Aghvami, Seyedmohammadali • LIU, Renwei
Assignees
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Publication Number
US-12714783-B2
Publication Date
2026-08-25
Expiration Date
Abstract
Methods and devices for dispensing a therapeutic composition from within a sealed container and drug delivery systems are described. The device and the method for dispensing a therapeutic composition from within a sealed container comprises a container configured to hold a therapeutic composition and include a first septum, a needle, a tube and an expandable membrane configured to expand out of the tube into an interior volume of the container to displace the therapeutic composition out of the container through the needle.
Core Innovation
The disclosure describes a filling device in which a tube and expandable membrane interact with a septum-sealed container holding a therapeutic composition. A reaction chamber contains reactants separated by a frangible barrier, wherein gas generated after mixing expands the membrane into the container to displace the composition through a needle. The composition is directed to a drug-delivery-device reservoir, a drug-delivery patch, or directly to a patient.
The disclosure additionally describes a drive arrangement utilizing a mechanical potential energy source positioned between drive housing portions, wherein a lock retains the portions in a retracted configuration. Unlocking the mechanism permits displacement of the container. The provided content omits background, abstract, and summary text, leaving any further stated account of the invention not explicitly described in the patent.
Claims Coverage
The claims define five inventive features across five independent claims: claims 1, 8, 12, 13, and 17, covering gas-expanded membrane devices and methods, a selectively couplable filling device, and lockable mechanical drive systems.
Gas-expanded membrane device
Claim 1 covers a device comprising a therapeutic-composition container, a needle, a tube, an expandable membrane, and a reaction chamber. The tube breaks a frangible barrier to allow reactants to generate gas, expanding the membrane into the container to displace the therapeutic composition through the needle.
Gas-expanded membrane method for expelling composition
Claim 8 covers a method for expelling therapeutic composition from a container using a needle, tube, flexible membrane, and reaction chamber. Gas generated by mixing reactants separated by a frangible barrier expands the membrane into the container and pressurizes its interior volume, allowing the composition to flow through the needle.
Filling device with removable housing
Claim 12 covers a filling device selectively couplable to a drug delivery device. A needle, tube, and expandable membrane displace therapeutic composition from a septum-sealed container through the needle, and a removable housing is configured to be removed with the filling device after the composition is provided to the drug delivery device reservoir.
Lockable mechanical drive with a potential energy source
Claim 13 covers a device comprising a container and a drive system with two drive housing portions, a lock, and a mechanical potential energy source between the portions. The lock retains the portions in a retracted configuration, and the potential energy source displaces the second portion and container upon unlocking.
Rotatable lock for a mechanical drive
Claim 17 covers a device comprising a container and a lockable drive system containing a mechanical potential energy source. A first lock portion is a slot in the first drive housing portion, and a second lock portion is a mechanically interfering structure rotatably connected to the second drive housing portion that rotates between locked and unlocked configurations.
The independent claims cover two approaches: gas-expanded membranes and filling devices configured to displace therapeutic composition from a container, and lockable mechanical drive systems that displace a container using a mechanical potential energy source.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Filling a reservoir of a drug delivery device with therapeutic composition.
Expelling therapeutic composition through a needle for delivery directly to a patient.
Transferring therapeutic composition into a drug-delivery patch.
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