Stabilization of selenite in a nutritional solution by dissolved oxygen
Inventors
DUPONT, Caroline • Bourezg, Zouaoui
Assignees
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Publication Number
US-12714725-B2
Publication Date
2026-08-25
Expiration Date
Abstract
The invention relates to a medical product for preventing or correcting selenium deficiency in a patient comprising a solution provided in a flexible container comprising at least one selenium compound in the form of Se(IV), which is preferably selected from the group consisting of sodium selenite, selenous acid and selenium dioxide, characterized in that the solution comprises dissolved oxygen (DO), preferably 0.5 ppm to 8 ppm DO.
Core Innovation
The disclosure describes a medical product for preventing or correcting selenium deficiency in a patient. It comprises an oxygen-impermeable flexible container holding a solution with a selenium compound in the form of Se(IV), selected from sodium selenite, selenous acid, and selenium dioxide, together with dissolved oxygen. The disclosure also describes a sterilized solution for parenteral administration contained in an oxygen-impermeable flexible container.
The description identifies selenium degradation in conditions of low oxygen and presents oxygen availability throughout storage as relevant to selenium stability. It reports improved selenium retention in oxygen-impermeable bags and describes stability after sterilization and in solutions containing additional trace elements. An oxygen-containing headspace is also described as an optional support for oxygen availability.
Claims Coverage
The claims include two independent claims covering a medical product and a sterilized solution for preventing or correcting selenium deficiency. Each independent claim has one main inventive feature.
Selenium solution in an oxygen-impermeable flexible container
The first independent claim covers a medical product comprising an oxygen-impermeable flexible container holding a solution with a selenium compound in the form of Se(IV), selected from sodium selenite, selenous acid, and selenium dioxide, and dissolved oxygen.
Sterilized parenteral selenium solution
The second independent claim covers a sterilized solution for parenteral administration comprising a selenium compound in the form of Se(IV), selected from sodium selenite, selenous acid, and selenium dioxide. The solution is formulated to prevent or correct selenium deficiency in a patient, comprises dissolved oxygen, and is contained in an oxygen-impermeable flexible container.
The independent claims cover selenium(IV) solutions with dissolved oxygen, contained in oxygen-impermeable flexible containers, for preventing or correcting selenium deficiency; one claim specifically covers a sterilized solution for parenteral administration.
Stated Advantages
Dissolved oxygen is associated with selenium stability, and the description reports improved selenium retention in oxygen-impermeable bags.
Documented Applications
Preventing or correcting selenium deficiency in a patient.
Parenteral administration of the sterilized selenium solution.
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