Techniques for determining medication correction factors in automatic medication delivery systems
Inventors
Lee, Joon Bok • Graham, James • O'Connor, Jason • Zheng, Yibin
Assignees
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Publication Number
US-12691222-B2
Publication Date
2026-07-28
Expiration Date
Abstract
Disclosed are processes and techniques for a correction factor determination process for determining a correction factor for delivering a drug to a patient via a drug delivery device. For example, for an insulin delivery device, the disclosed techniques enable adjustment of the patient's correction factor in real time based on the deviation of the patient's glucose concentrations against clinically recommended targets. For example, a method for determining a correction factor may include determining an insulin action (Iaction) for a patient over a duration, the insulin action representing a total insulin metabolized, determining glucose information for the patient over the duration, the glucose information representing glucose activity, and determining an estimated correction factor (CFest) based on (glucose information)/(insulin action) for the duration. Other embodiments are described.
Core Innovation
The disclosure describes controller- and method-based techniques for estimating a patient-specific medication correction factor from glucose activity and total insulin metabolized over a duration. The glucose activity is calculated based on meal ingestion during the duration versus the residual meal that is unabsorbed. The estimated correction factor is based on glucose information divided by insulin action and is used by an insulin delivery device to deliver an amount of insulin.
The described calculations include insulin action, glucose action and glucose meal excursion, and a weighted final correction factor; a duration of about four hours is identified in dependent claims. The supplied partial content does not include the background section, so the problem being solved in that section is not explicitly described in patent. The summary states that the approach adapts dosing to meals and changing patient sensitivity.
Claims Coverage
The relevant claims include two independent claims covering two inventive features: a controller for operating an insulin delivery device and a method for operating a drug delivery device.
Controller-based correction factor estimation
Claim 1 recites a controller with a processor and memory that determines insulin action for a patient over a duration, representing total insulin metabolized; determines glucose information representing glucose activity based on meal ingestion versus residual unabsorbed meal; and determines an estimated correction factor based on glucose information and insulin action. The estimated correction factor is used by the insulin delivery device to deliver an amount of insulin. Dependent claims further specify calculations for insulin action, glucose action, glucose meal excursion and a final correction factor, and identify a duration of about four hours.
Method-based correction factor estimation
Claim 10 recites determining, via a processor of a controller, insulin action for a patient over a duration, representing total insulin metabolized; determining glucose information representing glucose activity based on meal ingestion versus residual unabsorbed meal; and determining an estimated correction factor based on glucose information and insulin action. The estimated correction factor is used by the drug delivery device to deliver an amount of insulin. Dependent claims further specify calculations for insulin action, glucose action, glucose meal excursion and a final correction factor, and identify a duration of about four hours.
Both independent claims cover estimating an insulin correction factor by relating glucose information, accounting for meal ingestion and residual unabsorbed meal, to insulin action over a duration, and using the estimate for insulin delivery.
Stated Advantages
The correction factor adapts dosing to meals.
The correction factor adapts to changing patient sensitivity.
Documented Applications
Use of the estimated correction factor by an insulin delivery device to deliver insulin, including in automated drug delivery.
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