Analyte sensors employing multiple enzymes and methods associated therewith
Inventors
Oja, Stephen • Ouyang, Tianmei • Cho, Hyun • Tran, Lam N. • Feldman, Benjamin J.
Assignees
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Publication Number
US-12672804-B2
Publication Date
2026-07-07
Expiration Date
Abstract
Methods and analyte sensors including at least a first working electrode having a first active area thereon, and performing a dip coating operation to deposit a bilayer membrane upon the first working electrode and the first active area. The bilayer may include an inner layer having a first membrane polymer and an outer layer having a second membrane polymer, the first membrane polymer and the second membrane polymer differing from one another. The dip coating operation may comprise one or more first dips in a first membrane formulation to form the inner layer of the bilayer membrane and one or more second dips in a second membrane formulation to form the outer layer of the bilayer membrane upon the inner layer.
Core Innovation
The invention relates to a sensor control device for detecting glucose and ketones in vivo using a sensor having a reference electrode and two electrically isolated working electrodes. A ketones-responsive active area is disposed upon a first working electrode and a glucose-responsive active area is disposed upon a second working electrode, with the working electrodes electrically isolated from one another by a dielectric material.
The sensor is configured to be partially inserted into a user's skin so that a distal portion of the sensor is in contact with interstitial fluid to detect glucose and ketones in vivo, together with sensor electronics. To control analyte access to each active area, the sensor includes a mass transport limiting membrane structure having a first membrane disposed over the ketones-responsive active area and a second membrane disposed over the first membrane and the glucose-responsive active area, with different permeability values providing variable analyte permeability.
The sensor electronics determine ketone concentration and glucose concentration from first and second signals by applying a calibration curve for each analyte. The invention additionally provides sensor electronics configured for determining analyte concentrations and for handling separate analyte responses.
Claims Coverage
The partial content includes one independent claim. It contains multiple core inventive elements covering a two-working-electrode, electrically isolated sensor architecture with analyte-specific active areas, a mass transport limiting membrane with two membranes having different permeability values to provide variable analyte permeability to each active area, and in vivo skin insertion for interstitial-fluid detection with sensor electronics configured to determine analyte concentrations from separate signals using calibration curves.
Sensor control device for in vivo glucose and ketones detection
A sensor control device comprising a sensor with a reference electrode, a first working electrode having a ketones-responsive active area, and a second working electrode having a glucose-responsive active area, wherein the electrodes are electrically isolated by a dielectric material, the sensor is configured to be partially inserted into a user's skin so a distal portion contacts interstitial fluid to detect glucose and ketones in vivo, and sensor electronics.
Electrically isolated dual working electrode analyte-responsive active areas
A sensor in which a ketones-responsive active area is disposed upon a surface of a first working electrode and a glucose-responsive active area is disposed upon a surface of a second working electrode, with the first working electrode and second working electrode electrically isolated from one another by a dielectric material.
Variable analyte permeability using a mass transport limiting membrane with different permeability values
A mass transport limiting membrane comprising a first membrane disposed over the ketones-responsive active area and a second membrane disposed over the first membrane and the glucose-responsive active area, wherein the first and second membranes have different permeability values providing variable analyte permeability at the ketones-responsive active area and the glucose-responsive active area.
Determination of ketone and glucose concentrations from separate signals using calibration curves
Sensor electronics that determine ketone concentration and glucose concentration from first and second signals by applying a calibration curve for each analyte.
Across the independent claim, the main inventive coverage centers on an in vivo glucose-and-ketone sensor control device with two electrically isolated working electrodes, analyte-specific active areas, a two-layer mass transport limiting membrane providing variable analyte permeability via different permeability values, and sensor electronics that determine ketone and glucose concentrations from separate signals using calibration curves.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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