Coated electrode, electrochemical sensor and method for detection of hydrogen peroxide
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Publication Number
US-12663397-B2
Publication Date
2026-06-23
Expiration Date
Abstract
An electrochemical method for detecting hydrogen peroxide includes providing an electrochemical sensor comprising: a container holding an electrolyte; a coated electrode positioned in the container; and a counter electrode spaced apart from the coated electrode in the container, where the coated electrode includes a conductive substrate and a coating comprising a topological insulator on the conductive substrate. A voltage is applied to the coated electrode and the counter electrode, and a biological specimen is added to the electrolyte to form an analyte solution. Current density is measured. An increase in the current density upon forming the analyte solution indicates presence of hydrogen peroxide in the biological specimen.
Core Innovation
The disclosed invention is an electrochemical method for detecting hydrogen peroxide in a biological specimen. The method provides an electrochemical sensor with a container holding an electrolyte, a counter electrode spaced apart from a coated electrode, and a coated electrode positioned in the container. A voltage is applied to the coated electrode and the counter electrode, and an analyte solution is formed by adding the biological specimen to the electrolyte. The method measures current density, where an increase in current density upon forming the analyte solution indicates presence of hydrogen peroxide in the biological specimen.
The coated electrode includes a conductive substrate and a coating comprising flakes dispersed over the conductive substrate. The flakes have a lateral dimension larger than a thickness thereof and comprise a topological insulator comprising a bismuth and/or antimony chalcogenide. The topological insulator has a chemical formula selected from Bi2Se3, Bi2Te3, Sb2Te3, Sb2Se3, Bi2-xSbxTe3, or Bi2-xSbxSe3, where 0<x<2. The flakes comprise exposed facets having different crystalline domains and/or surface roughness.
The approach further defines hydrogen peroxide detection performance through a limit of detection and a sensitivity range tied to current-density measurement. The electrochemical sensor has a limit of detection of 0.02 µM or less of hydrogen peroxide. For analyte solutions including hydrogen peroxide at a concentration in a range from 0.02 µM to 65 µM, sensitivity of the measurement of current density is in a range from about 2500 µA/mM cm2 to 4905 µA/mM cm2.
Claims Coverage
The document contains two independent claims. The inventive coverage centers on an electrochemical method that links a topological-insulator flake-coated electrode to hydrogen peroxide detection via current-density increase, with stated performance limits of a limit of detection and a sensitivity range.
Electrochemical hydrogen peroxide detection using current-density increase with a topological-insulator flake-coated electrode
An electrochemical method for detecting hydrogen peroxide comprising providing an electrochemical sensor with a container holding an electrolyte, a coated electrode positioned in the container, and a counter electrode spaced apart from the coated electrode; applying a voltage to the coated electrode and the counter electrode; adding a biological specimen to the electrolyte to form an analyte solution; and measuring current density where an increase in the current density upon forming the analyte solution indicates presence of hydrogen peroxide in the biological specimen. The coated electrode includes a conductive substrate and a coating comprising flakes dispersed over the conductive substrate, the flakes having a lateral dimension larger than a thickness thereof and comprising a topological insulator comprising a bismuth and/or antimony chalcogenide with a chemical formula selected from Bi2Se3, Bi2Te3, Sb2Te3, Sb2Se3, Bi2-xSbxTe3, or Bi2-xSbxSe3, where 0<x<2, and the flakes comprising exposed facets having different crystalline domains and/or surface roughness. The electrochemical sensor has a limit of detection of 0.02 µM or less of the hydrogen peroxide.
Sensitivity-defined electrochemical hydrogen peroxide detection with current-density measurement
An electrochemical method for detecting hydrogen peroxide comprising providing an electrochemical sensor with a container holding an electrolyte, a coated electrode positioned in the container, and a counter electrode spaced apart from the coated electrode; applying a voltage to the coated electrode and the counter electrode; adding a biological specimen to the electrolyte to form an analyte solution; and measuring current density where an increase in the current density upon forming the analyte solution indicates presence of hydrogen peroxide in the biological specimen. For the analyte solution including hydrogen peroxide at a concentration in a range from 0.02 µM to 65 µM, a sensitivity of the measurement of current density is in a range from about 2500 µA/mM cm2 to 4905 µA/mM cm2.
The independent claims are directed to an electrochemical hydrogen peroxide detection method using a topological-insulator flake coating, where presence is indicated by an increase in measured current density. The claims further define performance by a limit of detection of 0.02 µM or less and a sensitivity range for hydrogen peroxide concentrations from 0.02 µM to 65 µM.
Stated Advantages
A limit of detection of 0.02 µM or less for hydrogen peroxide.
For 0.02 µM to 65 µM hydrogen peroxide, a sensitivity of the measurement of current density in a range from about 2500 µA/mM cm2 to 4905 µA/mM cm2.
Documented Applications
Detecting hydrogen peroxide in a biological specimen using an electrochemical method and measuring current density.
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