Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-12661173-B2
Publication Date
2026-06-23
Expiration Date
Abstract
A tissue treatment system configured to ablate a tissue, the system comprising: (a) a clamp assembly comprising a first jaw mechanism and a second jaw mechanism configured to receive and compress a tissue therebetween; (b) a first electrode disposed on the first jaw mechanism and configured to contact the tissue; and (c) a second electrode disposed on the second jaw mechanism and configured to contact the tissue, where the first electrode and the second electrode are configured so that at least one of an ablation energy output of the first electrode and an ablation energy output of the second electrode is automatically adjusted to accommodate variable tissue thicknesses between the first electrode and the second electrode.
Core Innovation
The invention relates to ablating a target tissue including myocytes by compressing the target tissue between a first jaw and a second jaw. The first jaw comprises a first electrode, and the second jaw comprises a second electrode. High-voltage pulses are delivered to the target tissue via at least one of the first electrode and the second electrode to non-thermally ablate the myocytes.
Non-thermal ablation is performed by delivering voltage pulses at or above 500 volts. The disclosure describes delivering about 5–50 pulses at about 1500–3000 Volts with pulse durations of about 0.02–0.1 milliseconds over a time interval of about 1–60 seconds. The delivery uses a bipolar arrangement and/or monopolar energy delivered via the first and/or second electrodes.
The disclosure further characterizes configuring compression geometry and energy delivery to accommodate variable tissue thickness. In some embodiments, the jaws compress tissue with a separation less than about 5 millimeters, and voltage pulses are automatically individually adjusted based on variable tissue thickness, including adjusting to deliver voltage pulses above about 500 Volts per centimeter. Embodiments also describe suction stabilizing the first and/or second electrodes and optionally synchronizing delivery with ventricular contraction.
Claims Coverage
The relevant set identifies one independent claim. The independent claim focuses on compressing myocyte-containing tissue between a first and second jaw electrodes and non-thermally ablating by delivering high-voltage pulses at or above 500 volts using a specified pulse regimen over a specified time interval.
Compressing target tissue between first and second jaw electrodes
Compressing a target tissue including myocytes between a first jaw comprising a first electrode and a second jaw comprising a second electrode.
Non-thermally ablating myocytes with voltage pulses at or above 500 volts
Non-thermally ablating the myocytes by delivering voltage pulses at or above 500 volts to the target tissue via at least one of the first electrode and the second electrode.
Delivering 5–50 pulses at about 1500–3000 Volts for about 0.02–0.1 ms over about 1–60 s
Delivering voltage pulses comprising about 5–50 pulses at about 1500–3000 Volts with pulse durations of about 0.02–0.1 milliseconds over a time interval of about 1–60 seconds.
Across the independent claim and associated dependents, the core inventive coverage centers on compressing myocyte-containing tissue between jaw electrodes and performing non-thermal ablation using high-voltage pulses at or above 500 volts with a specified pulse regimen over a defined time interval, with additional refinements including bipolar/monopolar operation, controlled compression geometry, automatic adjustment for variable tissue thickness, and optional suction stabilization and synchronization timing.
Stated Advantages
Non-thermally ablates myocytes by delivering voltage pulses at or above 500 volts.
Allows delivery of voltage pulses via bipolar and/or monopolar energy through the electrode(s).
Accommodates variable tissue thickness by automatically individually adjusting voltage pulses, including delivering voltage pulses above about 500 Volts per centimeter.
Maintains electrode coupling by adhering at least one of the first and second electrodes to target tissue using suction.
Improves timing alignment by synchronizing pulse delivery with ventricular contraction.
Documented Applications
Ablating cardiac tissue including myocytes, including for cardiac applications described with respect to atrial fibrillation.
Interested in licensing this patent?