Diagnostics systems and methods
Inventors
Galen, Peter • GURKAN, UMUT ATAKAN • HASAN, MUHAMMAD NOMAN • Bledsoe, James Daren • Witte, Tyler
Assignees
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Publication Number
US-12656310-B2
Publication Date
2026-06-16
Expiration Date
Abstract
A diagnostic system that includes a cartridge and a reader is discussed herein. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The reader contains various analysis systems, such as an electrophoresis detection system that uses electrophoresis testing to identify and quantify various components of the blood sample. The reader can process data from the various patient sample analysis to provide interpretative results indicative of a disorder, condition, disease, or infection of the patient.
Core Innovation
An electrophoresis detection system is provided that uses an illumination source to emit a first stimulus and a second stimulus during an assay run on an electrophoresis strip. The system includes processing circuitry programmed to generate an instruction causing the illumination source to emit the first stimulus and the second stimulus, and to receive multiple optical images of the electrophoresis strip at corresponding time points.
The processing circuitry detects band detection data based on the multiple optical images, where the band detection data includes detection characteristics generated from the first image and from the second image. The detection characteristic from each image includes band thickness and band speed of one or both of a first band and a second band in that image.
The system identifies a component associated with the band detection data based on the detection characteristic generated from the first image and the detection characteristic generated from the second image, and transmits an identifier of the component to an output.
Claims Coverage
The independent claim provides coverage of an illumination-and-imaging electrophoresis detection system with five inventive features.
First and second stimuli during an assay run
An illumination source is structured to, during an assay run on an electrophoresis strip, emit a first stimulus and a second stimulus, with processing circuitry programmed to generate an instruction to cause emission of both stimuli.
Multiple optical images at stimulus-dependent time points
Processing circuitry receives multiple optical images of the electrophoresis strip, including a first image captured at a first time point when the first stimulus is emitted and a second image captured at a second time point when the second stimulus is emitted.
Band detection characteristics from first and second images using band thickness and band speed
Band detection data is detected based on the multiple optical images, where the detection characteristic from each image includes band thickness and band speed of one or both of a first band and a second band.
Component identification based on detection characteristics from images
A component associated with the band detection data is identified based on the detection characteristic generated from the first image and the detection characteristic generated from the second image.
Transmit component identifier to an output
An identifier of the component is transmitted to an output.
Overall, the claims cover detecting image-derived band detection characteristics from multiple optical images captured under first and second stimuli, using those detection characteristics to identify an associated component, and transmitting a component identifier to an output.
Stated Advantages
Documented Applications
No documented applications found
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