Systems and methods for delivering neuroregenerative therapy
Inventors
Willand, Michael Patrick • Aguirre, Sergio David
Assignees
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Publication Number
US-12616832-B2
Publication Date
2026-05-05
Expiration Date
Abstract
Systems, devices and methods are disclosed for the treatment of injured peripheral nerves or other tissue using electrical stimulation. The systems can be used either in intraoperative or peri-operative settings and incorporate the use of either a plurality of monopolar electrodes with a patch used as return or a plurality of bipolar electrodes such as a cuff. The systems can provide hands-free delivery of electrical stimulation therapy over a predetermined set of time.
Core Innovation
The invention relates to neuroregenerative electrical stimulation of injured nerves in a subject, where at least one electrode assembly is positioned adjacent a target nerve percutaneously and is configured to be percutaneously removed from the subject through a percutaneous access point following delivery of stimulation energy. The method includes delivering stimulation energy to confirm at least one validation condition and then delivering stimulation energy to create a regenerative effect to the target nerve.
The stimulation energy used to confirm the at least one validation condition and the stimulation energy used to create the regenerative effect is provided by the same at least one electrode. The method further includes delivering stimulation energy having a first frequency to confirm at least one validation condition, and delivering stimulation energy having a second frequency via the at least one electrode assembly to create a regenerative effect.
The invention includes embodiments in which the stimulation delivery timing is intraoperative or postoperative, and the target nerve is described as a peripheral nerve. The electrode assembly can be configured as a bipolar electrode assembly, and the stimulation device can be removably secured on a subject’s skin surface using an adhesive patch.
Claims Coverage
Two independent methods are provided, each focused on percutaneously positioning an electrode assembly adjacent a target nerve, delivering stimulation energy to confirm validation conditions, delivering stimulation energy to create a regenerative effect, and percutaneously removing the electrode assembly after delivery. Across the independent claims, the coverage centers on the use of the same electrode assembly for both validation and regenerative-effect stimulation, with optional constraints including intraoperative or postoperative timing and a bipolar electrode assembly configuration.
Percutaneous electrode placement adjacent a target nerve with percutaneous removal
positioning at least one electrode assembly adjacent the target nerve, wherein the at least one electrode assembly is positioned adjacent the target nerve percutaneously, and wherein the at least one electrode assembly is configured to be percutaneously removed from the subject through a percutaneous access point following the delivery of stimulation energy
Validation-frequency stimulation using the same electrode assembly
delivering stimulation energy to the target nerve of the subject having a first frequency via the at least one electrode to confirm at least one validation condition, wherein stimulation energy to confirm at least one validation condition and to create a regenerative effect to the target nerve is provided by the same at least one electrode
Regenerative-effect stimulation at a second frequency using the same electrode assembly
delivering stimulation energy to the target nerve of the subject having a second frequency via the at least one electrode assembly, wherein delivering stimulation energy to the subject to create a regenerative effect to the target nerve
Intraoperative or postoperative delivery context
delivering stimulation energy to the target nerve of the subject during surgery (intraoperatively) or after surgery (postoperatively)
Bipolar electrode assembly configuration
the at least one electrode assembly includes a bipolar electrode assembly
Removably secured stimulation device on the skin surface using an adhesive patch
the stimulation device is removably attached to a subject’s skin surface using an adhesive patch
The claims cover percutaneous electrode-adjacent nerve stimulation in which stimulation is used first to confirm at least one validation condition and then to create a regenerative effect, with both functions provided by the same electrode assembly. The coverage further specifies optional timing contexts (intraoperative or postoperative), an optional bipolar electrode assembly configuration, and optional removably secured skin-surface attachment using an adhesive patch.
Stated Advantages
Documented Applications
No documented applications found
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