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Publication Number
US-12611509-B2
Publication Date
2026-04-28
Expiration Date
Abstract
A method of delivering a dose from a single dose syringe includes applying a user input to a rotational component of a plunger rod assembly that is engaged with a plunger rod of the plunger rod assembly to advance a plunger seal in a direction parallel to an axis of rotation of the rotational component from an initial position towards a start of dose delivery position, and upon disengagement of the rotational component from the plunger rod, applying an axial user input to the plunger rod of the plunger rod assembly to advance the plunger seal from the start of dose delivery position to a completion of dose delivery position to deliver the dose, wherein the completion of dose delivery position is defined by abutment between the plunger rod and a housing of the plunger rod assembly.
Core Innovation
A single dose syringe includes a barrel, a delivery conduit, and a plunger seal disposed within the barrel. A plunger rod assembly is affixed to an end of the barrel for advancing the plunger seal within the barrel to deliver a dose of a drug through the delivery conduit. The plunger rod assembly includes a housing mounted on the end of the barrel, a plunger rod disposed at least partially in the housing, and a rotational component configured to engage at least one protrusion of the plunger rod until a start of dose delivery position is reached.
A rotational user input to the rotational component initiates translation of the plunger seal toward the start of dose delivery position via engagement between the rotational component and the at least one protrusion. An axial user input is applied to the plunger rod to deliver the dose, and completion of the dose delivery is defined by an abutment between the plunger rod and the housing. The rotational component disengages prior to axial dose delivery.
The disclosed system further supports use cases involving delivery conduits such as a needle, attachable needle, attachable tubing connector, or an attachable microneedle array. Additional embodiments include feedback indicating that the start of dose delivery position has been set, including visual, aural, and/or tactile indication. In ophthalmic embodiments, the document describes prefilled syringe drug solutions with sub-visible particulates constrained by size and quantity thresholds, and the prefilled syringe is terminally sterilized.
Claims Coverage
The provided claim set includes two independent claims. Independent claim features cover a single-dose syringe actuation arrangement using rotational engagement to set a start-of-dose position followed by axial delivery with completion defined by abutment, and a corresponding two-stage method of delivering a dose with the same positional transition and completion definition by abutment.
Two-stage rotational engagement and axial delivery with abutment-defined completion
A single dose syringe with a barrel, a delivery conduit, a plunger seal disposed within the barrel, and a plunger rod assembly for advancing the plunger seal, where the plunger rod assembly includes a housing and a rotational component configured to engage at least one protrusion of the plunger rod until a start of dose delivery position is reached, a rotational user input initiates translation of the plunger seal toward the start of dose delivery position via engagement, an axial user input delivers the dose, and completion of dose delivery is defined by an abutment between the plunger rod and the housing.
Two-stage method using rotational advance to a start position then axial advancement to an abutment completion position
A method of delivering a dose from a single dose syringe where a user input is applied to a rotational component engaged with a plunger rod to advance the plunger seal from an initial position towards a start of dose delivery position, and upon disengagement of the rotational component, an axial user input is applied to advance the plunger seal from the start of dose delivery position to a completion of dose delivery position to deliver the dose, with completion defined by abutment between the plunger rod and a housing of the plunger rod assembly.
Across the independent claims, the core coverage is the same two-stage actuation concept: rotational engagement advances the plunger seal to a start of dose delivery position, and axial input delivers the dose to a completion position defined by abutment between the plunger rod and the housing.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Ophthalmic drug delivery via a prefilled syringe, including constraints on sub-visible particulates and terminal sterilization.
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