Pyrrole compounds

Inventors

Vendeville, Sandrine • Smith, David Bernard • Beigelman, Leonid • Serebryany, Vladimir

Assignees

Emory University • Aligos Therapeutics Inc

Abstract

Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Core Innovation

The disclosed subject matter encompasses substituted pyrrole compounds of Formula (I), including pyrrole-2-carboxamides bearing 2-oxoacetyl amino groups, stereoisomers, pharmaceutically acceptable salts, and prodrug forms. These compounds feature a substituted pyrrole linked to an aromatic, heteroaryl, or aza-aromatic ring with variable substituents, such as ethynyl oxetane, hydroxycyclobutyl, heterocycle, and pyrrolizine groups. The compounds are designated for pharmaceutical compositions and for treating or inhibiting HBV and/or HDV.

Biological assessments demonstrate antiviral activity with EC50 screening results below 1000 pM, indicating at least 16-fold greater potency than cited prior compounds. In addition, multiple disclosed compounds are reported not to form glutathione adducts in vitro. Because the background section and compound structures are omitted, the problem being solved is not explicitly described.

Claims Coverage

The supplied claim text identifies one inventive feature across two independent claims, claims 1 and 2.

The two independent claims cover compounds defined by structures omitted from the provided text, precluding identification of all elements of the claim or further claim elements not disclosed by the cited references.

Stated Advantages

Documented Applications