Systems and methods for simulating cardiovascular fluid flow
Inventors
FOREST-NAULT, Catherine • Guy, Aymeric • FEBRER, Guillaume
Assignees
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Publication Number
US-12594417-B2
Publication Date
2026-04-07
Expiration Date
Abstract
A system for simulating cardiovascular fluid flow having a target fluid flow profile, which has target pulsatile flow and target systemic resistance components, in a test member is disclosed. The system includes a reservoir, a pump, input and output channels, a first valve in the input channel, a second valve in the output channel, and a processor. The input and output channels are connectable to the test member so as to form a fluid circuit with the test member. The processor is configured to execute a method for controlling the first valve to generate the target pulsatile flow component in the input channel, and controlling the second valve to generate the target systemic pressure component. Other systems are also disclosed. Methods for simulating target fluid flow profiles in a test member are also disclosed.
Core Innovation
The disclosed subject matter relates to a cardiovascular perfusion simulation system for a test member that is non-viable, including cadavers, organ portions, and synthetic organs, when connected to a perfusion system to create a fluid circuit. The system includes a reservoir, a pump, input/output channels, a processor, and independently controlled valves configured to induce a target fluid flow profile in the fluid circuit.
The target fluid flow profile is decomposed into a target pulsatile flow component and a target systemic resistance component. An open-loop valve timing configuration is described using systole/diastole phases and a systole-to-diastole ratio, and a closed-loop mode is also described using flow/pressure sensors and real-time feedback to dynamically adjust valve opening and closing.
Multiple embodiments of the perfusion system are described, including different pump and valve configurations and an optional pulsatile flow pump chamber actuated by an actuator. The embodiments may include additional valves and check valves, and may include a separate pressure loop with one or more pressure-related valves. The processor uses input from sensor-measured fluid flow parameters to adjust preliminary valve parameters until measured parameters correspond to the target pulsatile flow component and the target systemic resistance component.
Claims Coverage
The partial content provides one independent claim (clm-00018). The claim specifies a processor-executed method that decomposes a target fluid flow profile into a target pulsatile flow component and a target systemic resistance component and uses sensor-based, iterative adjustment of a first input-channel valve and a second output-channel valve to match measured fluid flow parameters to the respective components.
Decomposing the target fluid flow profile into pulsatile and systemic resistance components
Obtain the target fluid flow profile, wherein the target fluid flow profile includes a target pulsatile flow component and a target systemic resistance component.
Sensor-feedback adjustment of the input-channel valve to match the pulsatile component
Control the first valve based on a preliminary first valve parameter, obtain input from a sensor of a measured fluid flow parameter in the input channel, and adjust the preliminary first valve parameter until the measured fluid flow parameter corresponds to the target pulsatile flow component.
Sensor-feedback adjustment of the output-channel valve to match the systemic resistance component
Control the second valve based on a second preliminary second valve parameter, obtain input from a sensor of a measured fluid flow parameter, and adjust the second preliminary second valve parameter until the measured fluid flow parameter corresponds to the target systemic resistance component.
Overall, the claim covers closed-loop, sensor-feedback control in a fluid circuit with independent input and output valves, using iterative adjustment so that measured flow parameters correspond respectively to a target pulsatile flow component and a target systemic resistance component.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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