Integrated, flexible, implantable, optical neural interrogation apparatus, computer-accessible medium, system, and method for use and implementation thereof
Inventors
Shepard, Kenneth L. • MOAZENI, SAJJAD • Pollmann, Eric
Assignees
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Publication Number
US-12594022-B2
Publication Date
2026-04-07
Expiration Date
Abstract
Exemplary embodiments of the present disclosure provide for an integrated, flexible, implantable, optical neural interrogation apparatus, computer-accessible medium, system, and method for use thereof. An integrated, flexible, fully-implantable, all-optical neural interrogation apparatus can include, e.g., a 2-dimensional (2D) planar array of optical photodetectors on an integrated electronic chip, the integrated electronic chip including control logic and image-capturing electronic circuitry, an amplitude or phase optical imaging mask for imaging, and a biocompatible packaging.
Core Innovation
An integrated, flexible, fully implantable all-optical neural interrogation apparatus is described for facilitating functional imaging of tissue. The apparatus includes an integrated electronic chip and a 2-dimensional (2D) planar array of optical photodetectors provided on the integrated electronic chip, together with control logic and image-capturing electronic circuitry. At least one of an amplitude optical imaging mask or a phase optical imaging mask is included, and the assembly is enclosed in biocompatible packaging.
The document further describes lens-less computational and time-gated approaches for 3D calcium/voltage fluorescence imaging using the planar photodetector array. The photodetector implementation is described as including SPAD pixels with an active quenching circuit, along with image capture and readout that supports fluorescence imaging and 3D reconstruction. The form factor is described as flexible, conformable, die-thinned, and fully implantable with biocompatible packaging thickness constraints.
Optogenetic functionality is described using 3D flip-chip bonded micro-LED arrays for providing optogenetic stimulation in patterns. Spatially selective and programmable stimulation patterns and stimulation depth are described to enable functional imaging together with optical stimulation. The apparatus is also described as including wireless power/data telemetry using an integrated multi-antenna ASIC and an external relay station for power/data and programming.
Claims Coverage
Two independent claims are identified. Across them, the claims share an integrated electronic chip with control logic and image-capturing circuitry, a 2D planar array of optical photodetectors, at least one amplitude or phase optical imaging mask, and biocompatible packaging, with one claim adding wireless power/data transmission between the implant and an external relay station.
Surgical implant with integrated chip and 2D planar photodetector array for functional imaging
a surgical implant comprising an integrated electronic chip; and a 2-dimensional (2D) planar array of optical photodetectors provided on the integrated electronic chip, wherein the integrated electronic chip includes control logic and image-capturing electronic circuitry.
Optical imaging mask integrated with biocompatible packaging for tissue functional imaging
at least one of an amplitude optical imaging mask or a phase optical imaging mask; and a biocompatible packaging.
Wireless transmission between implant and external relay station
control logic and image-capturing electronic circuitry to wirelessly transmit at least one of electrical power and data between the implant and an external relay station.
Method for facilitating functional imaging using a surgical implant with photodetector array
providing a 2-dimensional (2D) planar array of optical photodetectors on an integrated electronic chip, the integrated electronic chip including control logic and image-capturing electronic circuitry, at least one of an amplitude optical imaging mask or a phase optical imaging mask, and a biocompatible packaging.
Generating or obtaining functional image of tissue from photodetector array
generating or obtaining at least one functional image of the tissue using the provided 2D planar array of optical photodetectors.
The claim set centers on a surgical implant and method that provide functional imaging of tissue using a 2D planar array of optical photodetectors on an integrated electronic chip, with control logic and image-capturing circuitry, at least one amplitude or phase optical imaging mask, and biocompatible packaging. Dependent claim coverage further specifies features such as wireless transmission between the implant and an external relay station, and the generation or obtaining of functional images from the photodetector array.
Stated Advantages
Facilitates functional imaging of tissue using an implant that integrates optical photodetectors, control logic, and imaging masks within biocompatible packaging.
Enables wireless transmission of electrical power and data between the implant and an external relay station.
Supports generating or obtaining functional images of tissue using the provided 2D planar array of optical photodetectors.
Documented Applications
Functional imaging of tissue using a surgical implant.
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