Oral care compositions for gum health
Inventors
Biesbrock, Aaron Reed • Shi, Yunming • Strand, Ross
Assignees
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Publication Number
US-12582593-B2
Publication Date
2026-03-24
Expiration Date
Abstract
An oral care composition with retinoid compound, amino acid, and/or olive oil. An oral care composition with retinoid compound, a pentapeptide, such as palmitoyl KTTKS [SEQ ID NO. 2], and/or an olive oil. Methods of preventing gingival recession, stopping gingival recession, reversing gingival recession, decrease gum recession, increase gingival barrier protection, promoting collagen synthesis, promoting extracellular matrix synthesis, increasing gum resilience, increasing epidermal thickness and/or promoting fibrillin synthesis, in an oral cavity of an animal by contacting the oral care compositions with at least one surface of the oral cavity.
Core Innovation
The invention relates to a leave-on oral care composition for gum health. The composition includes a retinoid compound or retinol, a peptide selected from specific amino-acid sequences or combinations thereof, and PEGylated olive oil defined as a product of a reaction between olive oil and ethylene oxide, and it further includes a fluoride source in one emulsion embodiment.
The disclosure frames the problem as age-associated decline of the gingival epithelial barrier and collagen gene decreases. Improving gum health is associated with stopped or reversed gingival recession, increased epithelia thickness, increased collagen upregulation, and improved barrier protection.
A key aspect is the combination of the retinoid compound and the peptide together with the PEGylated olive oil component, which is reported to provide unexpectedly improved outcomes versus separate components. The described results include reduced MMP expression and reduced ROS, along with collagen upregulation and enhanced collagen-related markers, including collagen-1 ELISA enhancement associated with adding PEG-7 olive oil carboxylate to retinol plus peptide emulsions.
Claims Coverage
The partial content includes two independent claims. Each independent claim defines a leave-on oral care composition with specific ingredient selections plus defined rheology or mucoadhesion parameters.
Leave-on oral care emulsion with retinoid, specified peptide, PEGylated olive oil, fluoride, and yield stress
A leave-on oral care composition comprising about 0.01% to about 2% by weight of a retinoid compound; about 0.0001% to about 5% by weight of a peptide selected from glycine-histidine-lysine, glycine-glutamic acid-lysine-glycine, lysine-threonine-threonine-lysine-serine, and combinations thereof; about 0.01% to about 5% by weight of PEGylated olive oil where the PEGylated olive oil comprises a product of a reaction between olive oil and ethylene oxide; and a fluoride source; wherein the composition is an emulsion having a yield stress of about 2 Pa to about 250 Pa at 23°C.
Leave-on oral care gel with retinol, specified peptide, PEG-7 olive oil carboxylate, water content, and mucoadhesion
A leave-on oral care composition comprising about 0.01% to about 2% by weight of retinol; about 0.0001% to about 1% by weight of lysine-threonine-threonine-lysine-serine; about 0.01% to about 1% by weight of PEG-7 olive oil carboxylate or a salt thereof; and at least about 30% water, wherein the composition is in the form of a gel having a Viscosity Consistency Coefficient K of 20 Pa’s to 500 Pa’s as measured at 22°C at a shear rate range of 0.1-10 s-1 and a Mucoadhesion Index of no less than 0.3 Fluorescent Intensity Percentage.
Across the independent claims, the coverage centers on leave-on oral care compositions combining retinoids with specified peptides and PEGylated olive oil derivatives, together with fluoride in one embodiment and defined yield stress, viscosity consistency, and mucoadhesion parameters.
Stated Advantages
Stopped or reversed gingival recession.
Increased epithelia thickness.
Increased collagen upregulation.
Reduced MMP expression.
Reduced ROS.
Improved barrier protection.
Collagen-1 ELISA enhancement when adding Sodium PEG-7 olive oil carboxylate to retinol plus peptide emulsions.
Documented Applications
Improving gum health by applying a leave-on oral care composition to gum tissue and leaving it on the tissue for more than 2 minutes to provide a gum health benefit.
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