System, method, and computer program product for determining a needle injection site

Inventors

Galeotti, John MichaelChen, Edward

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Assignees

Member
Carnegie Mellon University
Carnegie Mellon University

Carnegie Mellon University is a global research institution based in Pittsburgh, Pennsylvania, recognized for interdisciplinary education, research, and innovation in science, engineering, arts, technology, and social sciences. The university leads advancements in artificial intelligence, robotics, digital health, and performing arts. Located in a technology-driven and culturally rich city, CMU powers real-world impact through research centers, industry engagement, workforce training, and initiatives that shape regional and global communities.

Publication Number

US-12579740-B2

Patent

Publication Date

2026-03-17

Expiration Date


Abstract

Provided is a system, method, and computer program product for determining a needle injection site. The method includes segmenting, with at least one computing device, an image of a sequence of images into at least one object based on a machine-learning model configured to estimate its uncertainty for each segmentation, generating, with the at least one computing device, a 3D model of the at least one object, and determining, with the at least one computing device, an insertion location of the at least one object based at least partially on an output of the machine-learning model.

Core Innovation

Not explicitly described in patent.

Not explicitly described in patent.

Claims Coverage

The provided independent claims are directed to a method, a system, and a computer program product, with a common core workflow of uncertainty-estimating segmentation of an image sequence, 3D model generation by filtering uncertain segmentation results using segmentation maps and uncertainty maps, and insertion-location determination based on the machine-learning model output. The inventive features focus on uncertainty estimation per segmentation, uncertainty-aware filtering for 3D reconstruction, and insertion-location determination using specific anatomical detections and scoring along an object.

Uncertainty-estimating segmentation of an image sequence

Segment an image of a sequence of images into at least one object based on a machine-learning model configured to estimate its uncertainty for each segmentation.

3D model generation by filtering uncertain segmentation results using segmentation and uncertainty maps

Generate a 3D model of the at least one object by filtering uncertain segmentation results based on segmentation maps and uncertainty maps output by the machine-learning model, including calculating an average uncertainty value for each segmented object and filtering by class based on an uncertainty threshold determined based on a predictive mean and a predictive variance output by the machine-learning model.

Insertion location determination based on machine-learning model output

Determine an insertion location of the at least one object based at least partially on an output of the machine-learning model.

Insertion location determination using bifurcation point and caudal end of a segmented ligament with total site scores

Determine an insertion location on the object based on a plurality of total site scores generated for different points along the object, including detecting a bifurcation point in the object in the 3D model, detecting a caudal end of a segmented ligament, and determining an insertion region between the bifurcation point and the caudal end of the segmented ligament.

Overall claim coverage ties uncertainty-estimating segmentation to uncertainty-aware 3D model generation via segmentation maps, uncertainty maps, average uncertainty, and class-based thresholds from predictive mean and predictive variance, and uses the machine-learning model output for insertion-location determination, further narrowed in the system claim to bifurcation-point and caudal-end detection of a segmented ligament with insertion-region definition and insertion selection based on total site scores along the object.

Stated Advantages

Documented Applications

No documented applications found

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