Non-invasive venous waveform analysis for evaluating a subject
Inventors
Hocking, Kyle M. • Brophy, Colleen M. • Eagle, Susan S. • Hocking, Grant
Assignees
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Publication Number
US-12575742-B2
Publication Date
2026-03-17
Expiration Date
Abstract
A method embodiment includes generating, via a sensor of a computing device, a signal representing vibrations originating from a blood vessel of a subject and decomposing the signal into one or more first intrinsic oscillatory modes and one or more second intrinsic oscillatory modes. The one or more first intrinsic oscillatory modes have respective oscillation frequencies that are less than respective oscillation frequencies of the one or more second intrinsic oscillatory modes. The method includes obtaining an intensity spectrum of the one or more first intrinsic oscillatory modes over a range of frequencies and using the obtained intensity spectrum to determine a blood volume status of the subject. Another method embodiment includes using the one or more second intrinsic oscillatory modes to determine one or more mechanical properties of the blood vessel or tissue adjacent to the blood vessel.
Core Innovation
A piezoelectric sensor generates a signal representing vibrations originating from a blood vessel of a subject. The signal is decomposed into one or more first intrinsic oscillatory modes and one or more second intrinsic oscillatory modes using a Hilbert-Huang transform or an ensemble empirical mode decomposition, and the first intrinsic oscillatory modes have respective oscillation frequencies that are less than respective oscillation frequencies of the second intrinsic oscillatory modes.
One or more second intrinsic oscillatory modes are used to determine one or more first mechanical properties of the blood vessel or a tissue adjacent to the blood vessel before a treatment is performed. Using the one or more second intrinsic oscillatory modes includes determining a Q-factor of the one or more second intrinsic oscillatory modes, and the first mechanical properties indicate arteriosclerosis, edema, and/or elevated risk of aneurysm.
An indication is provided via a user interface of a computing device that the one or more first mechanical properties indicate arteriosclerosis, edema, and/or elevated risk of aneurysm. Steps of generating the vibration signal and decomposing the signal are performed after the treatment to determine one or more second mechanical properties, and a change in a state of the blood vessel over time is quantified using the one or more first mechanical properties and the one or more second mechanical properties.
Claims Coverage
The independent claim set comprises three independent claims directed to a method, a computing device, and a non-transitory computer readable medium. Across these independent claims, the core coverage includes constrained modal decomposition, use of second intrinsic oscillatory modes including Q-factor, and a pre-treatment versus post-treatment assessment that quantifies change over time using mechanical properties indicating arteriosclerosis, edema, and/or elevated risk of aneurysm.
Vibration signal generation using a piezoelectric sensor
Generating, via a piezoelectric sensor, a signal representing vibrations originating from a blood vessel of a subject.
Modal decomposition into first and second intrinsic oscillatory modes
Decomposing the signal into one or more first intrinsic oscillatory modes and one or more second intrinsic oscillatory modes using a Hilbert-Huang transform or an ensemble empirical mode decomposition, wherein the first intrinsic oscillatory modes have respective oscillation frequencies that are less than respective oscillation frequencies of the second intrinsic oscillatory modes.
Pre-treatment mechanical properties from second intrinsic oscillatory modes and Q-factor
Using the one or more second intrinsic oscillatory modes to determine one or more first mechanical properties of the blood vessel or a tissue adjacent to the blood vessel before a treatment is performed, including determining a Q-factor of the one or more second intrinsic oscillatory modes.
Mechanical-property indication of arteriosclerosis, edema, and/or elevated aneurysm risk
Determining that the one or more first mechanical properties indicate arteriosclerosis, edema, and/or elevated risk of aneurysm and providing, via a user interface of a computing device, an indication that the one or more first mechanical properties indicate arteriosclerosis, edema, and/or elevated risk of aneurysm.
Post-treatment mechanical properties and quantification of change over time
Performing the signal generation and decomposition after the treatment is performed to determine one or more second mechanical properties of the blood vessel or the tissue adjacent to the blood vessel, and quantifying a change in a state of the blood vessel over time using the one or more first mechanical properties and the one or more second mechanical properties.
Across the independent claims, the inventive concept is the generation of blood-vessel vibration signals with a piezoelectric sensor, decomposition into lower-frequency first intrinsic oscillatory modes and higher-frequency second intrinsic oscillatory modes using a Hilbert-Huang transform or ensemble empirical mode decomposition, and use of the second intrinsic oscillatory modes, including determining a Q-factor, to determine mechanical properties indicating arteriosclerosis, edema, and/or elevated risk of aneurysm. The claims then repeat the signal processing after treatment to determine second mechanical properties and quantify a change in the blood-vessel state over time.
Stated Advantages
Provides an indication via a user interface that mechanical properties indicate arteriosclerosis, edema, and/or elevated risk of aneurysm.
Quantifies a change in a state of the blood vessel over time using mechanical properties determined before and after a treatment.
Documented Applications
Diagnosing or treating arteriosclerosis, edema, and/or elevated risk of aneurysm by determining mechanical properties of a blood vessel or adjacent tissue before and after a treatment.
Diagnosing or treating a disorder selected from: hypervolemia, hypovolemia, euvolemia, dehydration, heart failure, tissue hypoperfusion, myocardial infarction, hypotension, valvular heart disease, congenital heart disease, cardiomyopathy, pulmonary disease, arrhythmia, drug effects, hemorrhage, systemic inflammatory response syndrome, infectious disease, sepsis, electrolyte imbalance, acidosis, renal failure, hepatic failure, cerebral injury, thermal injury, cardiac tamponade, preeclampsia, eclampsia, and toxicity.
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