Automatic titration with defibrillation sensitivity compensation

Inventors

Libbus, Imad • Stubbs, Scott • KenKnight, Bruce

Assignees

Livanova USA Inc

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Publication Number

US-12569682-B2

Patent

Publication Date

2026-03-10

Expiration Date


Abstract

A method of delivering neurostimulation therapy to a patient from an implantable medical device is provided. The method includes delivering, by the implantable medical device, the neurostimulation therapy to the patient. The method further includes determining, by the implantable medical device, that the patient has received a defibrillation shock from a defibrillation device. The method further includes adjusting, by the implantable medical device, the neurostimulation therapy based on determining that the patient has received the defibrillation shock.

Core Innovation

The invention provides automatic titration of neurostimulation therapy from an implantable medical device in a patient who has received a defibrillation shock. The implantable medical device delivers the neurostimulation therapy and determines that the patient has received the defibrillation shock from a defibrillation device, then adjusts the neurostimulation therapy based on that determination.

The determination is based on receiving indications related to the defibrillation shock, including wireless communication from a defibrillation device, physiological signals such as electrocardiogram (ECG/EKG) waveform changes, and sensing based on voltage. In some examples, the device determines receipt when an in-patient voltage signal stays above a voltage threshold for longer than a preset time duration.

After determining that the patient has received the defibrillation shock, the device compensates the titration by suspending stimulation and/or pausing or reducing intensity, and then resuming titration from reduced intensity for a predetermined period. The document also describes patient confirmation-enabled modes, including a magnet swipe and/or a smartphone app prompt, and references titration aggressiveness profiles.

Claims Coverage

The independent claims cover three inventive features: delivering and adjusting neurostimulation therapy based on determining receipt of a defibrillation shock, determining shock receipt from a sensor signal and reducing therapy intensity accordingly, and an implantable medical device configured to perform these operations using processing circuits and stored instructions.

Adjusting neurostimulation therapy based on determining defibrillation shock receipt

Delivering neurostimulation therapy to a patient; determining that the patient has received a defibrillation shock from a defibrillation device; and adjusting the neurostimulation therapy based on determining that the patient has received the defibrillation shock.

Reducing neurostimulation therapy intensity based on sensor-signaled defibrillation shock receipt

Delivering neurostimulation therapy to a patient; receiving a signal from a sensor of the implantable medical device; determining that the patient has received a defibrillation shock from a defibrillation device based on the signal received from the sensor; and reducing an intensity of the neurostimulation therapy based on determining that the patient has received the defibrillation shock.

Implantable medical device to deliver and adjust neurostimulation therapy based on defibrillation shock receipt

An implantable medical device comprising at least one processing circuit including at least one processor and at least one memory, with instructions that cause the processor to perform operations including delivering neurostimulation therapy to a patient; determining that the patient has received a defibrillation shock from a defibrillation device; and adjusting the neurostimulation therapy based on determining that the patient has received the defibrillation shock.

Across the independent claims, the coverage focuses on determining receipt of a defibrillation shock from a defibrillation device and adjusting neurostimulation therapy accordingly, including therapy intensity reduction based on a sensor signal and implementation in an implantable medical device using stored instructions.

Stated Advantages

Documented Applications

No documented applications found

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