System and method for multi-coil steerable and selectively focussed transcranial magnetic stimulation
Inventors
Carmona Tortolero, Ivan C. • Hadimani, Ravi L. • BARON, Mark S. • Kumbhare, Deepak
Assignees
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Publication Number
US-12564727-B2
Publication Date
2026-03-03
Expiration Date
Abstract
An example method includes positioning above the transcranial region, an arrangement of solenoids, and selecting a target zone from among a plurality of zones. A zone-specific set of Q solenoids is identified from the arrangement of solenoids, based on the target zone. The zone-specific set includes a pair of mutually adjacent ones of the solenoids. A Q-element solenoid feed modulation state vector is generated, which defines a Q-current element feed current modulation state. The Q-current element feed current modulation state is configured to cause the zone-specific set of Q solenoids to generate Q individual, spatially configured, time-varying magnetic fields that, in combination, establish a transcranial magnetic stimulation (TMS) inducing time-varying magnetic field, which induces a target hotspot TMS electric field. The hotspot TMS electric field is focalized to the target zone.
Core Innovation
The method establishes a selectively focusable and steerable electric field within a transcranial region. It selects a target zone, identifies a zone-specific set of mutually adjacent solenoids, and feeds the solenoids individually modulated currents. Their spatially configured, time-varying magnetic fields combine to induce a target hotspot TMS electric field focalized to the target zone.
A further method establishes and actively constrains a moving electrical charge flow through biological tissue along a depth-aligned flow path. A central solenoid and peripheral solenoids generate time-varying magnetic fields that average to a central electrical field. Inward repulsive forces urge against charges in the central flow to constrain charge flow toward a target region.
Claims Coverage
The two independent claims describe two inventive features: selectively focusing and steering a transcranial magnetic stimulation electric field, and inducing and constraining electrical charge flow through biological tissue.
Selectively focused and steered transcranial electric field
The method selects a target zone, identifies a zone-specific set of mutually adjacent solenoids, and feeds them individually modulated currents. Their spatially configured, time-varying magnetic fields combine to induce a target hotspot TMS electric field focalized to the selected zone.
Constrained electrical charge flow through biological tissue
The method positions a central solenoid aligned with a target region and peripheral solenoids around it. The combined magnetic fields produce a charge-inducing central electrical field, while inward repulsive forces urge against central-region charges and constrain their flow along a depth-aligned path.
The independent claims cover a solenoid arrangement for focusing and steering a TMS electric field to a selected transcranial zone, and a central and peripheral solenoid arrangement for inducing and constraining charge flow through biological tissue.
Stated Advantages
The arrangement is described as improving target-region focality.
Documented Applications
Establishing a selectively focusable and steerable TMS electric field within a transcranial region, focalized to a selected target zone.
Establishing and actively constraining a moving electrical charge flow through biological tissue along a depth-aligned path.
Neuromodulation research.
Treatment of neurological or psychiatric disorders.
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